肾血管平滑肌脂肪瘤10例临床病理分析  

Renal angiomyolipoma: a clinicopathological analysis of 10 cases

作　　者：李新建[1] 任素珍[2] 张玉兰[3] 严军宁[3] 李发言 

机构地区：[1]中铁四局集团中心医院病理科 [2]安徽省立儿童医院病理科 [3]合肥市第一人民医院病理科,安徽合肥230000

出　　处：《安徽医药》2005年第9期676-677,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨肾血管平滑肌脂肪瘤的临床病理特征及鉴别诊断。方法对10例肾血管平滑肌脂肪瘤进行HE染色,光镜观查,其中7例进行免疫组化(S-P法)染色。结果肿瘤组织学形态示畸形血管,平滑肌细胞,脂肪组织以不同比例出现,其中4例可见异型增生的上皮样平滑肌细胞。免疫组化:梭形及上皮样平滑肌细胞都特征性表达HMB45,SMA。HMB45的表达强度与平滑肌细胞的上皮样分化,细胞核的异型度成正比。结论免疫标记物HMB45、SMA的联合应用在该病的鉴别诊断中具有重要价值。Aim To investigate the clinical pathological features and differential diagnosis of renal angiomyolipoma（AML）. Methods 10 cases of AML were studied by using HE staining, of which 7 cases were also studied by using immunohistochemistry （ S-P method）. Result Histologically, the tumor showed three tissue components of blood vessels , smooth muscle cells and fat cells in varied proportion. There were atypical epithelioid smooth muscle cells in 4 cases. Immunohistochemically , both spindle and epithelioid smooth muscle cells were characteristically positive for HMB -45 and SMA, and the HMB-45 is usually stronger in epithelioid and pleomorphic smooth muscle cells . Conclusion Immunohistochemical stains may elucidate the correct diagnosis.

关 键 词：肾血管平滑肌脂肪瘤 临床病理学 鉴别诊断 免疫标记物 

分 类 号：R737.11[医药卫生—肿瘤]