电离辐射攻击性大剂量与小鼠生殖细胞适应性反应  

CHALLENGING RADIATION DOSES ON TRE ADAPTIVE RESPONSE OF MOUSE GERM CELLS

作　　者：王彬[1] 姜杰[1] 王献理[1] 

机构地区：[1]白求恩医科大学放射医学研究所

出　　处：《辐射研究与辐射工艺学报》1996年第2期107-110,共4页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金

摘　　要：以０．０５Ｇｙ的Ｘ射线为Ｄ１剂量，预先对雄性昆明种小白鼠进行适应性照射，然后以０．７５～３．７５Ｇｙ的Ｘ射线为Ｄ２剂量，进行攻击性照射，观察其精原细胞、初级精母细胞染色体畸变和精原干细胞染色体易位的适应性反应。其结果表明，三种细胞在０．７５～３．００Ｇｙ之间都出现了不同程度的适应性反应现象，３．７５Ｇｙ适应性反应不明显。说明适应性反应是有一定限度的，即Ｄ２的剂量是有一定范围的。Kunming male mice were irradiated by 0.05 Gy X-rays as theadaptive irradiation dose, then were exposed to 0.75-3.75Gy X-rays as the challenging irradiation doses. The chromosome aberrations in spermatogonia and spermatocytes and translocations in stem cells were observed. The results showed that theadaptive response appeared from 0.75-3.00Gy in all three kinds of cell. but theadaptive response was not obvious when the dose was 3.75 Gy. Those results indicated the challenging doses of irradiation had the adaptive response within limits.

关 键 词：大剂量辐射 生殖细胞 染色体畸变 辐射损伤 

分 类 号：R818.87[医药卫生—放射医学] R818.03[医药卫生—临床医学]