急性脑梗死病人血清瘦素与白细胞介素6水平的变化  

CHANGES OF LEPTIN AND INTERLEUKIN-6 IN PATIENTS WITH ACUTE CEREBRAL INFARCTION

作　　者：徐广印[1] 陈永生[1] 

机构地区：[1]临沂市人民医院神经内科,山东临沂276003

出　　处：《齐鲁医学杂志》2005年第6期483-484,共2页Medical Journal of Qilu

摘　　要：①目的探讨急性脑梗死病人血清瘦素、白细胞介素6水平的变化。②方法60例脑梗死病人,入院后第2天抽取空腹静脉血,用ELISA法检测血清瘦素及白细胞介素6水平,同时检测21例健康成人血清作为对照。③结果脑梗死组瘦素及白细胞介素6水平显著高于对照组(t′=6.67,t=4.65,P<0.01)。④结论急性脑梗死存在高瘦素血症和瘦素抵抗,瘦素水平增高是急性脑梗死的危险标志。白细胞介素6参与了急性脑梗死的发生发展。Objective To study the changes of interleukin-6 （IL-6） and leptin in patients with acute cerebral infarction. Methods Blood samples from 60 patients with cerebral infarction and 21 controls were collected. The levels of leptin and IL-6 were detected by radioimmunoassay. Results Serum leptin and IL-6 levels in the patients were higher than those in normal controls （t′=6.67,t=4. 65,P〈0.01）. Conclusion There is hyperleptinemia and leptin resistance in acute cerebral infarction. High serum leptin is a risk sign of acute infarction. IL-6 is involved in the occurrence and development of the disease.

关 键 词：瘦素 白细胞介素6 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]