急性白血病病人血清sICAM-1和sVCAM-1水平检测  

DETECTION OF SERUM sICAM- 1 AND sVCAM-1 LEVELS IN PATIENTS WITH ACUTE LEUKEMIA

作　　者：汪洪毅[1] 王新卫[1] 王伟[1] 

机构地区：[1]青岛大学医学院附属医院血液内科,山东青岛266003

出　　处：《青岛大学医学院学报》2005年第4期289-291,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的探讨细胞间黏附分子-1(ICAM-1,CD54)和血管细胞黏附分子-1(VCAM-1,CD106)在急性白血病病人诊断、病情进展、疗效观察及预后判断中的意义.②方法采用酶联免疫吸附测定方法(ELISA法),对19例急性淋巴细胞白血病(ALL)和36例急性非淋巴细胞白血病(ANLL)病人治疗前后的血清可溶性ICAM-1(sICAM-1)和可溶性VCAM-1(sVCAM-1)水平进行检测并与正常人比较.③结果急性白血病病人化疗前血清sICAM-1和sVCAM-1水平升高,与正常对照组比较差异有显著性(F=11.52、10.73,q=3.06～4.17,P<0.01),缓解后降至正常水平.复发病人血清sICAM-1和sVCAM-1水平升高,与缓解组及正常对照组比较差异有显著性(F=8.91、9.12,q=2.92～4.93,P<0.01).ANLL中M4和M5病人血清sVCAM-1水平高于其他亚型病人(F=8.13、9.11,q=3.65～4.13,P<0.05).血清sICAM-1和sVCAM-1水平升高者与血清sICAM-1和sVCAM-1水平正常者比较,疗效较差.随着病情缓解,血清sICAM-1和sVCAM-1水平亦降至正常.④结论血清sICAM-1和sVCAM-1水平的检测有助于判断病人的病情进展、疗效及预后,并对化疗方案的选择有一定的指导作用.Objective To evaluate the significance of sICAM-1 and sVCAM-1 in the diagnosis, development of clinical status, treatment outcome, and prognosis of patients with acute leukemia. Methods Serum samples were obtained from 19 acute lymphocytic leukemia （ALL） and 36 acute non-lymphocytic leukemia （ANLL） patients before and after treatment. All serum samples were measured for concentrations of sICAM-1 and sVCAM-1 with enzyme linked immunosorbent assay （ELISA） method. Results Serum levels of sICAM-I and sVCAM I in acute leukemia patients elevated significantly before treatment compared with normal controls and reduced to normal levels after remission. Serum levels of sICAM-1 and sVCAM-1 in relapsed acute leukemia patients also elevated significantly compared with normal controls. Serum levels of sVCAM-1 in M4 and Ms were higher than other subtypes in ANLL patients. Patients with elevated serum levels of sICAM-1 and sVCAM-1 had poorer treatment outcomes. Serum levels of sICAM-1 and sVCAM-1 were found to return to normal at remission. Conclusion The detection of sICAM-1 and sVCAM-1 in acute leukemia patients is conducive to the judgement of the development of clinical status, treatment outcome and prognosis. It can also be a subsidiary indicator to make out a proper scheme for chemotherapy.

关 键 词：白血病 可溶性 细胞黏附分子 血管细胞黏附分子-1 

分 类 号：R733.71[医药卫生—肿瘤]