蛋白激酶C在H IV复制中的作用与药物发现  

The roles of protein kinase C in HIV replication and drugs discovery

作　　者：张高红[1] 唐宏[2] 郑永唐[1] 

机构地区：[1]中国科学院昆明动物研究所云南昆明 [2]中国科学院微生物研究所,北京100080

出　　处：《中国药理学通报》2005年第9期1025-1029,共5页Chinese Pharmacological Bulletin

基　　金：国家高技术研究发展计划(863计划)资助项目(No2003AA219142);中国科学院知识创新工程重要方向(NoKSCX2-SW-216);国家自然科学基金(No30471605);"十五"国家科技攻关计划项目(No2004BA719A14);云南省自然科学基金(No2002C0066M2003C0022R);云南省科技攻关计划(No2004NG12)资助课题

摘　　要：蛋白激酶C(PKC)是一类磷脂依赖的丝氨酸/苏氨酸蛋白激酶,PKC在中枢神经系统疾病及心血管紊乱等多种人类疾病中都发挥了重要作用。研究发现,PKC可以通过多种途径刺激H IV病毒的活化,并磷酸化病毒复制周期中的多种蛋白,如P17gag、Nef、Rev和V if等,这些蛋白的磷酸化在病毒复制周期中起到了不可忽视的作用。了解PKC与H IV及细胞间的复杂关系,开发抑制PKC蛋白激酶的药物从而达到抑制H IV复制的目的,或激活PKC从而减少或消除体内潜伏的H IV病毒库是对PKC在抗H IV研究中应用提出的两个主要方向,对于开发新型抗H IV药物有重要意义。Protein kinase C （ PKC ） belongs to the family of phospholipid-dependent serine/threonine kinase. PKC signaling has been implicated in the development of multiple human diseases including the central nervous system dysfunctions and cardiovascular disorders. It has been demonstrated that PKC can stimulate viral activation through multiple mechanisms and phosphorylate the HIV-1 p17 gag,Nef,Vif and Rev proteins as well. The phosphorylation of these proteins may have significant effects on HIV replication. Members of the PKC family participate at many levels in diverse signaltransduction pathways involved in HIV cycles. PKC inhibition may be considered a logical mechanism which inhibits HIV-1 replication. Agents that induce HIV-1 replication could be used in conjunction with HAART to decrease or eliminate the latent reservoirs by forcing viral expression. A better understanding of the role of PKC could in form the search of specific target for new anti-HIV therapies.

关 键 词：蛋白激酶C HIV 信号转导 磷酸化 

分 类 号：R-05[医药卫生] R345.57