烟酰水杨酸对鹌鹑实验性动脉粥样硬化的预防作用  

Preventive effect of nicotinyl salicylic acid on experimental atherosclerosis in quails

作　　者：朱敏恒[1] 丁一上[1] 吴越[1] 刘洪海[1] 杨德林[1] 

机构地区：[1]石河子大学药物研究中心,新疆石河子832002

出　　处：《中国药理学通报》2005年第9期1074-1078,共5页Chinese Pharmacological Bulletin

基　　金：国家重点科技攻关计划资助项目(No96-901-01-70)

摘　　要：目的探讨烟酰水杨酸(N icotinylsalicylic ac id,NSA)对高脂饲料诱导的鹌鹑实验性动脉粥样硬化的预防作用。方法91只♂朝鲜种鹌鹑,随机分为6组,组1:普通饲料组(对照组)、组2:高脂饲料组(造模组)、组3:高脂饲料+NSA150 mg.kg-1.d-1、组4:高脂饲料+NSA 300 mg.kg-1.d-1、组5:高脂饲料+烟酸75 mg.kg-1.d-1+乙酰水杨酸75 mg.kg-1.d-1、组6:高脂饲料+烟酸150 mg.kg-1.d-1。动态监测(0、4和8 wk)其血浆总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和丙二醛(MDA),8 wk末处死动物,观察主动脉及左、右头臂动脉病理变化和TC、TG含量;观察心脏病理变化。结果高脂饲料可使鹌鹑血脂发生紊乱,血浆TC、TG水平增加,LDL-C、MDA明显升高,HDL-C水平下降;主动脉及左、右头臂动脉壁TC、TG含量升高,并有明显的动脉粥样硬化斑块形成。NSA可降低高脂饲料喂养的鹌鹑血浆TC、TG、LDL-C、MDA水平,升高HDL-C水平,动脉壁TC、TG含量降低,主动脉及左、右头臂动脉的AS斑块形成减轻。结论NSA对高脂饲料诱导的鹌鹑实验性动脉粥样硬化有预防作用。Aim To investigate the preventive effect of nicotinylsalicylic acid （ NSA ） on experimental atherosclerosis in high cholesterol-fed quails. MethodsNinety one male quails were randomly divided into six groups：group I , normal control; group Ⅱ, model control;group Ⅲ, NSA 150 mg·kg^-1·d^-1; group Ⅳ NSA 300 mg· kg^-1 . d^- 1 ; group V, the nicotinic acid 75 mg·kg^-1·d^- 1 and the aeetylsalieylie acid 75 mg·kg^-1·d^-1; group Ⅵ, the nicotinic acid 150 mg·kg^-1·d^-1. The levels of TC,TG, HDL-C, LDL-C and MDA in serum were measured with biochemical method （0,4,8 wks）. All of the quails were killed after 8 wks. Variables observed included aorta pathologic changed, TC and TG contents and the heart pathologic changes. Results The experimental data indicated that the high cholesterol-feeding increased the level of TC,TG, LDL-C and MDA, decreased the level of HDL-C in serum, aortic wall have obvious atherosclerosis. Data of the study demonstrated that the level of TC, TG, LDL-C and MDA were decreased, the level of HDL-C were increased by NSA in the high cholesterolfed quails, aortic wall TC, TG were decreased by NSA, and atherosclerosis was regressed in aortic wall. Conclusion NSA has preventive effect on the experimental atherosclerosis among the high cholesterol-fed quails.

关 键 词：烟酰水杨酸 动脉粥样硬化 烟酸 

分 类 号：R-332[医药卫生] R322.11