小剂量辐射影响B16黑色素瘤血道肺转移作用机制研究  

MECHANISM OF LOW DOSE X-RADIATION INFLUENCING B16 MELANOMA BLOOD-BORNE PULMONANY METASTASES

作　　者：魏道严[1] 金敖兴[1] 黄帼[1] 江思应 左祥生[1] 

机构地区：[1]安徽医科大学核医学教研室,安徽医科大学肿瘤研究室,安徽医科大学第一附属医院

出　　处：《辐射研究与辐射工艺学报》1996年第2期101-103,共3页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金

摘　　要：Ｃ５７ＢＬ／６小鼠经７．５ｃＧｙＸ线全身照射后２４ｈ静脉注射１２５ＩＵｄＲ标记的Ｂ１６黑色素瘤细胞，２４ｈ后测定肺活瘤细胞存留率时发现，照射组小鼠的肺活瘤细胞存留率明显降低。与此同时，于照射后２４ｈ检测小鼠的免疫功能发现，照射组小鼠脾脏有核细胞数明显增多，脾细胞ＮＫ细胞毒活性及体内巨噬细胞功能均显著增强。结果提示，小剂量辐射可能通过提高ＮＫ细胞、巨噬细胞功能而加速肺肉瘤细胞的清除速率。After whole body exposed to 7.5 cGy X-ray. the C57 BL/6 micewere I. V. injected with 125IUdR labelled B16 melanoma cells, the proportion ofsurviving labelled cells retained in lungs was detected at 24 hours after injection,andfound that the surviving cells in the lungs of irradiated mice were significa'ntlydecreased. Meanwhile, the immunofunctions were tested at 24 hours after irradiation.the results showed that the number of nucleate cells and NK cytotoxity in spleens,and the phagocytotic function of macrophages in vivo were increased obviously forthe irradiated mice. The results suggested that the enhancement of NK cytotoxityand macrophage phagocytotic function might be one of the\ important reasons forlow dose radiation accelerating the clearance of tumor cells from the lungs.

关 键 词：小剂量辐射 黑色素瘤 肺转移 免疫功能 放射疗法 

分 类 号：R730.55[医药卫生—肿瘤] R734.2[医药卫生—临床医学]