双环铂及其衍生物对大鼠靶器官毒性损伤的比较  

The Comparison Study of Major Target Organ Hurt Induced by Dicycloplatin and Its Derivates in Rats

作　　者：林飞[1] 吕廉[1] 杨旭清 崔维川 王凤敏 

机构地区：[1]中国药品生物制品检定所,北京100050 [2]北京兴大科学系统公司,北京100081

出　　处：《癌变．畸变．突变》2005年第5期276-279,共4页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：国家"十五"科技攻关重大专项课题(No.2003AA273162)

摘　　要：背景与目的:观察连续静脉注射双环铂、卡铂和卡铂+环丁烷二甲酸后,对大鼠产生的毒性反应,并比较3种铂类化合物毒性反应的大小。材料与方法:3种受试物各分成2个给药组(5mg/kg和15mg/kg)和1个溶剂对照组。间断给药3个周期,每个周期连续尾静脉注射给药5d,停药9d。结果:在相同的剂量下,3种受试物对大鼠均有不同程度的毒性作用,主要的毒性靶器官为血液系统、消化系统、生殖系统。卡铂毒性偏重于骨髓造血系统的抑制和肾功能的损伤;双环铂毒性偏重于生殖细胞的损伤;环酸毒性处于二者之间。结论:3种铂类化合物毒性大小依次为:卡铂>环酸>双环铂。BACKGROUND ＆ AIM： To observe the toxicity effect and the extent on rats via tail venous continuously injection dicycloplatin, carboplatin and carboplatin added cyclobutane dicarbonylic acid, and compare the degree of toxicity in the three kinds of platinum. （5 mg/kg, 15 mg/kg）for every tested drug were injected via tail venous for five days There is different are blood system, system of marrow MATERIAL AND METHODS： The rats were divided into two dosage groups and one negative control group. There are three continuously and quitted the drugs for nine days disposed periods. in every period. The drugs RESULTS： extent toxicity effect on rats of the three kinds of tested drugs at same dosage. The major target organ digestive system and reproductive system. The toxicity effect of carboplatin hemopoiesis and damaging the function of kidney, and the toxicity effect of dicycloplatin stresses on damaging the germ cell, but carboplatin added cyclobutane dicarbonylic acid between them. CONCLUSION： Summarizing the toxicity effect of the three tested drugs, the sequence size of the toxicity effect is carboplatin, carboplatin added cyclobutane dicarbonylic acid and dicycloplatin.

关 键 词：双环铂 卡铂 环丁烷二甲酸 大鼠 长期毒性 静脉注射 毒性损伤 靶器官 衍生物 铂类化合物 

分 类 号：R742[医药卫生—神经病学与精神病学] R979.1[医药卫生—临床医学]