肺癌患者血清MMP-9，Endostatin，VEGF水平及临床意义  

Elevated Serum Levels of MMP-9、Endostatin and VEGF in Lung Cancer and Its Clinical Significance

作　　者：李雪冰[1] 李宝兰[1] 赖百塘[1] 朱允中[1] 张新勇[1] 戈启萍[1] 湛秀萍[1] 王玥[1] 

机构地区：[1]北京市结核病胸部肿瘤研究所

出　　处：《结核病与胸部肿瘤》2005年第3期170-173,共4页Tuberculosis and Thoracic Tumor

摘　　要：目的测定肺癌患者血清中MMP-9，endostatin，VEGF水平，探讨其在肺癌中的特异性及与化疗的关系。方法应用酶联免疫吸附法（ELISA），测定三种因子在144例肺癌患者血清中的表达。结果肺癌患者血清MMP-9、endostatin、VEGF水平显著高于健康人及肺良性病患者（P〈0．001）；肺癌患者血清MMP-9、endostatin及VEGF水平与肿瘤组织类型、有无远处转移、临床分期及原发肿瘤大小相关（P〈0．05）；化疗后VEGF、endostatin水平变化与疗效相关，有显著性差异（P〈0．001）；肺癌患者血清MMP-9，endostatin水平呈正相关（r=0．260，P=0．012）。结论肺癌患者血清MMP-9，endostatin，VEGF水平明显升高．在肺癌的病理疾病过程中有特殊意义，可作为预测肺癌恶性行为和治疗反应的良好指标。Objective To study the relationship between serum levels of MMP-9,endostatin,VEGF and the clinical pathophysiological characteristics in lung cancer patients. Methods Serum levels of MMP-9,endostatin and VEGF were detected in 144 patients with lung cancer by ELISA method. Results The serum levels of MMP-9,endostatin and VEGF in lung cancer patients were significantly higher than those in patients with benign pulmonary diseases and healthy group （P〈0.001）.The serum levels of endostatin and VEGF in lung cancer patients were closely correlated with its histological classification,type of tumor,TNM-stages, size of tumor and distant metastasis（P〈0.05）.The changes of serum endostatin and VEGF in lung cancer patients after chemotherapy were correlated with the effect of treatment （P〈0.001）.The serum level of MMP-9 in lung cancer patients was highly positively correlated with serum endostatin level in lung cancer patients（r=0.260,P=0.012）. Conclusion The serum level of MMP-9,endostatin and VEGF of patients with lung cancer are significantly elevated this might be used to forecast the malignant change of lung cancer and the response to chemotherapy.

关 键 词：肺肿瘤 基质金属蛋白酶-9 内皮抑素 血管内皮生长因子 酶联免疫吸附测定 血清MMP-9 ENDOSTATIN 肺癌患者 水平变化 VEGF 

分 类 号：R734.2[医药卫生—肿瘤] R979.1[医药卫生—临床医学]