丹皮酚及其磺化物体外抗氧化作用  

Antioxidative Function of Paeonol and Sodium Paeonol Sulfonate

作　　者：吴晓慧[1] 吴国荣[1] 张卫明[2] 顾龚平[2] 沈奇[1] 

机构地区：[1]南京师范大学生命科学学院,江苏南京210097 [2]南京野生植物综合利用研究院,江苏南京210042

出　　处：《南京师大学报（自然科学版）》2005年第3期83-85,共3页Journal of Nanjing Normal University(Natural Science Edition)

基　　金：江苏省高校省级重点实验室开放研究课题(164070301402)

摘　　要：为比较研究丹皮酚及其磺化物的体外抗氧化作用,测定了丹皮酚及其磺化物体外清除超氧阴离子自由基(O2.—)、羟自由基(.OH)的活性及对过氧化氢(H2O2)、紫外线(UV)诱导红细胞溶血的影响.发现丹皮酚和丹皮酚磺化物均具有较强的清除O2.—、.OH及抗H2O2、UV诱导的红细胞(RBC)溶血的活性,后者的抗氧化效应更强,甚至在一定程度超过作为阳性对照物的抗坏血酸.可以认为丹皮酚和丹皮酚磺化物可成为高效的天然抗氧化剂新资源.In order to investigate the difference of the antioxidative function among paeonol and sodium paeonol sulfonate. The clearing function on superoxide anion （ O2^- ） and hydroxy radical （ ·OH ） , and the inhibition on H2O2 ,UV-induced hemolysis of RBC of paeonol and sodium paeonol sulfonate were evaluated in the paper. And the paper also showed that Paeonol and sodium paeonol sulfonate had strong clearing function on O2^-, ·OH and inhibition on H2O2, UV-induced hemolysis of RBC. The later had a better antioxidative function and exceeds ascorbic acid which is commonly used as positive control drug in some aspect. We can conclude that paeonol and sodium paeonol sulfonate will be new resource of natural antioxidants.

关 键 词：丹皮酚 丹皮酚磺化物 氧自由基 溶血 抗氧化 

分 类 号：Q946[生物学—植物学]