宫颈腺癌癌胚抗原表达的意义  

The Significance of CEA Expression in Adeno carcinoma of the Cervix Uteri

作　　者：李新英[1] 焦书竹[1] 

机构地区：[1]天津医科大学总医院妇产科

出　　处：《中国肿瘤临床》1996年第5期315-318,共4页Chinese Journal of Clinical Oncology

摘　　要：用ＡＢＣ免疫组织化学技术，对３５例宫颈腺癌、１０例正常宫颈及慢性宫颈炎组织进行了ＣＥＡ研究。结果，宫颈腺癌ＣＥＡ的阳性率为７４．３％（２６／３５），不同组织分型的ＣＥＡ阳性率虽无差异，但ＣＥＡ着色强度及分布具有一定特征。外生型腺癌的ＣＥＡ阳性率为４５．４％（５／１１），低于内生型的８５．７％（１２／１４）及溃疡型的９０％（９／１０）（Ｐ＜０．０５）。无瘤生存期≥３年组的ＣＥＡ阳性率４４．４％（４／９），低于＜３年组的８５％（１７／２０）。本文提示宫颈腺癌ＣＥＡ表达及分布特征有助于其组织学类型的鉴别，并对其患者的预后判断有重要价值。CEA expression was studied with ABC immunohistochemical technique, using paraffin embedded pretreatment tumor biopsies taken from 35 cases of adenocarcinoma of cervix, 10 cases of normal cervix and chronic cervicitis as control. The results showed that the positive rate of CEA in the adenocarcinoma were 74. 3% , but none in normal cervix and chronic cervicitis. Although histopathologic patterns and grades were not significantly related to CEA positive rate, their staining location and intensity of CEA had some distinguishing features.The CEA positive rate in exophytic type tumors (45.4%) was significantly lower than endophytic type tumors(85.7%)and ulcer type tumors(90%)(P<0. 05). The follow up results showed that CEA positive rate(44.4%)in Patients who have been survived for over 3 years without recurrence was significantly lower than those who survived less than 3 years (85%)(P<0.05). The study indicated that CEA expression has important value to predict the prognosis of patients with cervical adenocarcinoma. It may be helpful in the distinction of histopathological patterns of cervical adenocarcinoma.

关 键 词：宫颈腺癌 免疫组织化学 诊断 预后 癌胚抗原 

分 类 号：R737.33[医药卫生—肿瘤]