芳香基苯并咪唑衍生物的合成、表征及抑菌活性研究  

Synthesis, Structure and Antimicrobial Activity of Aromatic Benzimidazole Derivatives

作　　者：田敏[1] 王陆瑶[1] 陈邦[1] 史真[1] 

机构地区：[1]西北大学化学系,西安710069

出　　处：《化学通报》2005年第9期709-713,共5页Chemistry

基　　金：国家自然科学基金(20172041);陕西省自然科学基金(2000H01)资助项目

摘　　要：在微波辐射下,通过二茂铁磺酰氯和相应的苯并咪唑合成了4种芳香基苯并咪唑衍生物。经1HNMR、MS及元素分析确证产物结构。通过X线衍射测定了化合物4a的晶体结构。用琼脂稀释法测定化合物抑菌活性,并与对照药剂50%多菌灵可湿性粉剂比较,结果表明化合物4a～4d对番茄早疫病菌、烟草赤星病菌和小麦赤霉病菌有与对照药剂近似的抑菌活性。Four compounds of aromatic benzimidazole derivatives were obtained by the reaction of ferrocenesulfonyl chloride and the corresponding benzimidazoles under microwave. The compounds were characterized by means of ^1H NMR, MS, and elemental analysis. The crystal structure of 4a was determined by single crystals Xray diffraction. The antimicrobial activity was tested in vitro against five fungicides in comparison with the 50% carbendazim wet powder.

关 键 词：苯并咪唑衍生物 合成 微波辐射 单晶结构 抑菌活性 苯并咪唑衍生物 抑菌活性 活性研究 合成 香基 多菌灵可湿性粉剂 表征 二茂铁磺酰氯 番茄早疫病菌 

分 类 号：TQ450.1[化学工程—农药化工]