活络益脑汤择时用药对实验性大鼠脑出血模型血流变学指标的影响  

Effect of administration of huo-luo-yi-nao decoction in time-choosing on hemorrheology mark of intracerebral hemorrhage rats

作　　者：周云静[1] 程宜福[1] 

机构地区：[1]皖南医学院附属弋矶山医院中医科,安徽芜湖241001

出　　处：《皖南医学院学报》2005年第4期257-259,共3页Journal of Wannan Medical College

摘　　要：目的通过测定血液流变学指标和脑组织含水量,探讨活络益脑汤择时给药对大鼠脑出血急性期的治疗作用机理及最佳用药时间点。方法将造模成功的脑出血大鼠随机分为模型3 d组、模型生理盐水组、汤药3个时间用药组,分别于造模后3 d与15 d后测血液流变学指标、脑系数与脑组织含水量。结果给药15 d后各治疗组大部分血液流变学指标恢复正常值上下,而以9时用药组更接近正常值。结论活络益脑汤对大鼠脑出血的血液流变学指标和脑水肿有明显改善作用。Objective To study the protective effect and determine the best the time-choosing in administration of the traditional Chinese medicine complex, huo-luo-yi-nao decoction（HYN）, on the intracerebral hemorrhage （ICH） rats. Methods The ICH rats were randomly divided into five groups （MYS, TYJS, TYSW, TYCG）. Hemorrheology marker, cerebral exponent and water weight contained in cerebral tissue were measured respectively after treatment in 3 and 15 days. Results The findings showed that above marks of the rats given therapy returned to normal value in 15 days（P 〉0.05）, Especially , the more excellent effect was observed in the ninth hour group than that in the two other groups（P〈0.05）. Conclusion Huo-luo-yi-nao decoction can play role in changing hemorrheology marker and encephaledema of ICH rats.

关 键 词：脑出血 活络益脑汤 血液流变学 脑水肿 大鼠 

分 类 号：R743.34[医药卫生—神经病学与精神病学]