骨髓活检塑包法在多发性骨髓瘤诊断中的价值  

Evaluation of plastic-embedded method on bone marrow biopsy in diagnosing patients with multiple myeloma

作　　者：张岱云[1] 汪兴洪[2] 黄东平[2] 张军[1] 

机构地区：[1]皖南医学院附属弋矶山医院细胞室,安徽芜湖241001 [2]皖南医学院附属弋矶山医院血液科,安徽芜湖241001

出　　处：《皖南医学院学报》2005年第4期260-261,共2页Journal of Wannan Medical College

基　　金：安徽省教育厅自然科学研究基金项目(2004kj338)

摘　　要：目的了解骨髓活检在多发性骨髓瘤诊断与鉴别诊断中的价值。方法运用塑料包埋切片技术观察32例多发性骨髓瘤患者的骨髓象表现,同时与骨髓涂片进行比较。结果多发性骨髓瘤骨髓切片中浆细胞以结节状和片状浸润为主,这类浸润方式对多发性骨髓瘤诊断的敏感性(90.6%)明显高于涂片中浆细胞>15%的指标(65.6%)。切片中骨髓增生程度也明显高于涂片。结论骨髓活检塑包切片法更能正确反映骨髓组织的真实情况,对多发性骨髓瘤的诊断、疗效判断方面的价值优于涂片。Objective To find out the evaluation of bone marrow biopsy method in differential diagnosis for patients with multiple myeloma（MM）. Methods The embedded sections in plastic of biopsy and the smears of 32 patients with MM were observed and compared. Results The infiltration pattern of plasma cells in born marrow sections was mainly regarded as nodular and packed. The sensitivity of the infiltration patterns to diagnosis of MM was 90.6 % and higher than that of the smears （65.6 % ）. This findings suggested that the infiltration pattern of plasma cells in sections could objectively reflect tumour burden and clinical stage of patients with MM for the degree of cellularity in sections was higher than in smears. Conclusion This method is necessary to the differential diagnosis for its evaluation of therapeutical effect and prognosis of multiple myeloma.

关 键 词：骨髓活检 塑料包埋 多发性骨髓瘤 

分 类 号：R733.3[医药卫生—肿瘤]