卵巢透明细胞癌70例临床特点及预后分析  

Clinical analysis of 70 patients with clear cell carcinoma of ovary

作　　者：路虹[1] 王雁[1] 孔为民[1] 

机构地区：[1]首都医科大学附属北京妇产医院肿瘤科,北京100006

出　　处：《肿瘤防治杂志》2005年第16期1263-1264,1278,共3页China Journal of Cancer Prevention and Treatment

摘　　要：探讨卵巢透明细胞癌的临床、病理特点及预后,回顾性分析我院1982年1月～2001年12月70例原发性卵巢透明细胞癌患者临床资料,对其临床特点与治疗情况进行总结并对预后进行随访,总结其发病规律及临床特点.卵巢透明细胞癌多以腹痛、腹胀和盆腔包块为主要症状(占就诊者80%),70例患者全部进行手术,满意肿瘤细胞减灭术5年生存率(61.5%)与不满意肿瘤细胞减灭术5年生存率(7.69%)差异有统计学意义.术后病理组织证实单纯透明细胞癌42例,透明细胞癌合并其他上皮性癌28例,合并子宫内膜异位症19例.共65例于术后进行了PT、PAC等化疗.在不同方案、不同疗程比较中,发现PT方案、6个疗程以上化疗组有较高的5年生存率,与PAC组、其他化疗方案组差异有统计学意义,P=0.005.卵巢透明细胞癌临床特点不同于其他的卵巢上皮恶性肿瘤,是上皮癌的一种特殊组织类型,其临床分期早,化疗不敏感,即使是早期亦易复发,预后较差,应引起重视.手术尽量行理想的肿瘤细胞减灭术,术后行6个疗程以上的PT方案化疗,可望改善疗效.The objective of this study was to study the clinical characteristics of clear cell carcinoma of the ovary. Seventy patients with ovarian clear cell carcinoma who were treated in our hospital from Jan 1982 to Dec 2001 were studied retrospectively. The 5-year survival rate of those patients who underwent satisfactory cytoreductive surgery was significantly higher than that of the patients who had residual tumors more than 2 cm diameter after surgery. After surgery auxiliary chemotherapy was conducted in 65 patients. The patients conducted with TP （ Taxol and PPD or CBP） more than 6 cycles had higher 5-year survival rate than those with other chemotherapy regimes or less than 6 cycles. In conclusion, the clear cell carcinoma of ovary is different from other epidermic carcinomas of ovary. It is a special epidermic carcinomas of ovary and its stage is earlier and is not sensitive to chemotherapy. The cytored uctive surgery should be performed as far as possible. Postoperative chemotherapy with more than 6 cycles of TP regime could have better results.

关 键 词：卵巢肿瘤/外科手术 卵巢肿瘤/药物疗法 腺癌 透明细胞 存活率 

分 类 号：R737.31[医药卫生—肿瘤]