精氨酸对胃肠道肿瘤患者术后红细胞免疫功能的影响  

Effects of arginine on post-operative red blood cell immune function of patients with gastrointestinal tumors

作　　者：宋德余[1] 刘防震[1] 薛雅静[1] 王文娟[1] 高增书[1] 

机构地区：[1]哈励逊国际和平医院胃肠外科,河北衡水053000

出　　处：《肿瘤防治杂志》2005年第18期1379-1381,共3页China Journal of Cancer Prevention and Treatment

基　　金：河北省科研技术研究与发展计划项目(042761201)

摘　　要：目的:探讨精氨酸对胃肠道肿瘤患者术后红细胞免疫功能的影响。方法:将我院应用含有精氨酸的胃肠外营养支持的胃肠道肿瘤患者38例作为研究组,不含有精氨酸的胃肠外营养支持的胃肠道肿瘤患者36例作为对照组。分别于术前、术后第1天、术后第7天测定患者的红细胞免疫功能,红细胞C3b受体花环率(RCR)、红细胞免疫复合物花环率(RICR)和肿瘤红细胞花环率(TRR)。结果:术前:研究组RCR、RICR和TRR分别为16·23%、15·35%和32·14%,对照组RCR、RICR和TRR分别为16·45%、14·96%和31·15%,两组患者的红细胞免疫功能比较无统计学意义,P>0·05;术后第1天:研究组RCR、RICR和TRR分别为15·34%、15·65%和30·56%,对照组RCR、RICR和TRR分别为15·10%、16·31%和30·78%,两组患者的红细胞免疫功能比较无统计学意义,P>0·05;术后第7天:研究组RCR、RICR和TRR分别为18·65%、13·31%和35·21%,对照组RCR、RICR和TRR分别为15·10%、15·36%和30·78%,研究组患者的红细胞免疫功能高于对照组,差异有统计学意义(RICR:t=2·42,P=0·012;RCR:t=9·20,P=0·001:TRR:t=5·59,P=0·0014)。结论:精氨酸可促进胃肠道肿瘤患者术后免疫功能的恢复。OBJECTIVE： To explore the effect of arginine on post operative red blood cell immune function of patients with gastrointestinal tumors. METHODS： Thirty-eight patients with gastrointestinal tumors by parenteral nutrition （PN） with arginine were selected as the study group： 36 patients with gastrointestinal tumors by PN without arginine as the control group. Red blood cell C3b, receptor rosette （RCR）. red blood cell immune complex rosette （RICR）and tumor red blood cell rosette （TRR） in the two groups were detected on the day before the operation and the postoperative days 1 and 7. RESULTS： Before the operation, RCR, RICR. TRR in the study group were 16.23%, 15.35% 32.14% respectively, and RCR, RICR. TRR in control group were 16. 45%, 14.96%, 31. 15% respectively, and so the red blood cell immune function between the two groups was not significantly different. P=0.05; the postoperative day 1. RCR. RICR. TRR in the study group were 15.34%, 34%, 15.65%, 30. 56%, and RCR, RICR. TRR in the control group were 15.10%, 16. 31%, 30. 78% respectively, and red blood cell immune function between the two groups was not significantly different. P〉0. 05; the postoperative day 7. RCR. RICR. TRR in the study group were 18. 65%, 13.31%, 35.21 % respectively. RCR. RICR. TRR in the control group were 15. 10%, 15. 36%, 30. 78% respectively, and the red blood cell immune fupction in the, study group was higher than that in the control group. there were significant differences. P〈0. 05, P〈0. 01. CONCLUSION： Arginine can promote the recovery of post-operative red blood cell immune function of patients with gastrointestinal tumors.

关 键 词：胃肠肿瘤/外科学 红细胞/免疫学 精氨酸/药理学 

分 类 号：R735[医药卫生—肿瘤]