手性铝试剂促进的β-环氧醇动力学拆分研究  

Kinetic Resolution of β-Hydroxy Epoxides Promoted by Chiral Aluminium Reagents

作　　者：王少华[1] 王飞[1] 张辅民[1] 樊春安[1] 涂永强[1] 任世阔[1] 

机构地区：[1]兰州大学化学化工学院功能有机分子化学国家重点实验室,兰州730000

出　　处：《有机化学》2005年第10期1302-1305,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.29925205;30271488;20021001;203900501)资助项目.

摘　　要：首次以手性联萘酚修饰的三乙基铝为催化剂对消旋的β-环氧醇的动力学拆分进行了研究,初步研究结果表明其回收原料的ee值可达60%.同时研究了不同条件下三乙基铝与手性配体形成的手性路易斯酸对β-环氧醇的动力学拆分的影响,并探讨了在三乙基铝催化下的反应机理.The first kinetic resolution of β-hydroxy epoxides has been studied through chiral aluminium reagents, which gave the recovered starting material with 60% ee. Various conditions were explored for the kinetic resolution of β-hydroxy epoxide by chiral aluminium reagents. A possible mechanism was proposed for the reaction by aluminium reagent.

关 键 词：三乙基铝 β-环氧醇 手性联萘酚 动力学拆分 环氧醇 手性 铝试剂 路易斯酸 研究结果 反应机理 

分 类 号：O643.1[理学—物理化学]