宫颈疾患中人巨细胞病毒核酸的检测  

DETECTION OF HUMAN CYTOMEGALOVIRUS DNA SEQUENCE IN CERVICAL UTERINE LESIONS

作　　者：孙瑜[1] 孟祥金[1] 刘朝奇[1] 杨平[1] 伍欣星[1] 赵文先[1] 李新志[1] 张有新[1] 

机构地区：[1]湖北医学院病毒研究所

出　　处：《肿瘤》1989年第5期206-207,共2页Tumor

摘　　要：人巨细胞病毒(HCMV)是一种DNA病毒,属疱疹病毒科,可存在于精液内,通过性传播。已知HCMV与前列腺癌、结肠癌和卡波氏肉瘤(KaposisSarcoma)等人类肿瘤存在病因关系,近年来在人宫颈癌中的作用也愈来愈受到人们的重视。Pacsa等报道,启颈不典型增生患者血清HCMV抗体水平比正常人高;Melnick等从宫颈癌活检组织或宫颈癌组织培养细胞中分离到HCMV,且宫颈癌活检组织中也测到了HCMV DNA序列。本文通过对各种类型的宫颈疾患中HCMVSixty nine biopsy specimens from cervical uterine lesions (40 cervical cancer, 11cervical dysplasia and 18 cervicitis) were studied for the presence of human cytome-galovirus DNA sequence by using dot blot hybridization method. The positive rates ofHCMV DNA sequence in cervical cancer group (73%) and in cervieal dysplasis gruoup(73%) were both statistically higher (P<0.05) than that in cervicitis group (44%).The result indicated that HCMV may associate with cervical cancer.

关 键 词：子宫肿瘤 巨细胞病毒 核酸检测 

分 类 号：R737.33[医药卫生—肿瘤]