宫颈疾患中人巨细胞病毒抗原及其血清抗体的检验  

DETECTION OF CYTOMEGALOVIRUS ANTIGENS AND AHTIBODY IN CERVICAL LESIONS

作　　者：孙瑜[1] 盂祥金 汪慧民[2] 曾维坤 胡伧颖 李新志[1] 张有新[1] 

机构地区：[1]湖北医学院病毒研究所 [2]湖北省医学科学院病毒所 [3]湖北医学院附二院妇产科

出　　处：《肿瘤防治研究》1989年第1期17-20,共4页Cancer Research on Prevention and Treatment

摘　　要：应用补体结合试验(CFT)及免疫酶标玻片法(IPA)对宫颈癌高发区的正常妇女和宫颈癌低发区正常妇女,宫颈糜烂及宫颈癌病人血清人巨细胞病毒(CMV) IgG抗体进行了测定,并用过氧化物酶抗过氧化物酶(PAP)法检测了宫颈疾患活检组织中的CMV抗原;结果表明,宫颈癌高发区的正常妇女、低发区宫颈糜烂和宫颈癌病人血清CMVIgG抗体滴度的几何均数(GMT)均比低发区正常人高,经统计学处理差别具有高度显著性(P<0.01);IPA法与CFT法的检测结果相符,但IPA法较CFT法敏感;CMV抗原的检出率在宫颈糜烂为30％,宫颈癌为36％。实验结果提示,宫颈疾患中CMV感染较普遍,宫颈癌的发生可能与CMV有关。Sera from normal women of cervical cancer high risk district and low risk district cervical erosion and cervical cancer were detected for the presence of ytomegalovirus antibody,also the CMV antigens were detected by peroxidase anti-peroxidase(PAP)method, it shows that the GMT of CMV antibody in cervicalcancer high risk district, cervicaI erosion and cervical cancerpatients was higherthan the GMT of CMV antibody in cervical cancer low risk district patients, thedifference was statistically significant (P<0.01), the results of IPA and CFT me-thods was no diference, but the IPA method was more sensitive than CFT method.CMV antigens were detected in 30% cervical erosion and 36% cervical cancer. Theresults indicate that the infection of CMV in cervical lesions was very common,CMV may associated with the development of cervical cancer.

关 键 词：子宫肿瘤 人巨细胞病毒 抗原 抗体 

分 类 号：R737.303.3[医药卫生—肿瘤]