晚期上颌窦鳞癌组织中GST-π和PCNA的表达与预后的关系  

Correlation of GST-π and PCNA Expression to Prognosis of Advanced Maxillary Sinus Squamous Cell Carcinoma

作　　者：郭桂芳[1,2] 谢汝华[1,2] 杨安奎[1,2] 陈直华[1,2] 吴秋良[1,3] 刘巍巍[1,2] 区深明[1,2] 夏良平[1,2] 陈明远[1,2] 张晋昕[4] 

机构地区：[1]华南肿瘤学国家重点实验室 [2]中山大学肿瘤防治中心综合三科,广东广州510060 [3]中山大学肿瘤防治中心病理科,广东广州510060 [4]中山大学中山医学院统计学教研室

出　　处：《癌症》2005年第10期1267-1271,共5页Chinese Journal of Cancer

基　　金：广东省科委重点攻关项目(No.0068-100171)~~

摘　　要：背景与目的:细胞增殖与代谢相关的肿瘤标志物在上颌窦癌的研究较少。本研究旨在探讨晚期上颌窦鳞癌谷胱甘肽S-转移酶-π(glutathioneS-transferaseπ,GST-π)和增殖细胞核抗原(proliferatingcellnuclearantigen,PCNA)的表达与预后的关系。方法:选取晚期上颌窦鳞癌组织54例,上颌窦良性肿瘤组织29例,正常鼻腔粘膜组织20例。免疫组化法检测标本组织中GST-π和PCNA的表达。Kaplan-Meier法评估晚期上颌窦鳞癌GST-π和PCNA的表达水平与预后的关系;Cox回归模型进行多因素预后分析。结果:上颌窦鳞癌组织中的GST-π和PCNA高表达率显著高于良性肿瘤组织和正常组织(74.1%vs.89.6%和15.0%,P<0.01;79.6%vs.3.4%和0,P<0.01)。单因素生存分析表明GST-π低表达组与高表达组的5年生存率分别为34.5%与21.2%,差别有统计学意义(P=0.025),PCNA低表达组与高表达组的5年生存率分别为18.0%与27.0%,差别无统计学意义(P=0.890)。多因素生存分析显示GST-π的表达(P=0.039,OR>1)对生存率的影响有统计学意义。结论:GST-π表达是影响晚期上颌窦鳞癌预后的独立因素;PCNA表达水平与生存无关。BACKGROUND ＆ OBJECTIVE： Tumor markers which relate to cell proliferation and metabolism have seldom been studied in maxillary sinus cancer. This study was conducted to identify the correlation of glutathione S- transferase π （GST-π） and proliferating cell nuclear antigen （PCNA） expression to prognosis of advanced maxillary sinus squamous cell carcinoma （SCC）. METHODS： The expression of GST-π and PCNA in 54 specimens of maxillary sinus SCC, 29 specimens of benign maxillary tumor, and 20 specimens of normal nasal mucosa was detected by immunohistochemistry. The correlation of GST-π and PCNA expression to prognosis of advanced maxillary sinus SCC was analyzed by Kaplan-Meier method. The prognosis was analyzed by Cox multivariate model. RESULTS： The overexpression rates of GST-π and PCNA were significantly higher in maxillary sinus SCC than in benign maxillary tumor and normal nasal mucosa （74.1% vs. 89.6% and 15.0%, P〈0.01; 79.6% vs. 3.4% and 0, P〈0.01）. The 5-year survival rate was significantly higher in advanced maxillary sinus SCC patients with high expression of GST-π than in the patients with low expression of GST-π （34.5% vs. 21.2%, P=0.025）; the difference between the patients with high and low expression of PCNA was not significant （18.0% vs. 27.0%, P=0.890）. The expression of GST-π was an independent prognostic factor of advanced maxillary sinus SCC （P=0.039, odds ratio〉1）. CONCLUSION： The overexpression of GST-π is an independent prognostic factor of advanced maxillary sinus SCC, but that of PCNA isn＇t.

关 键 词：上颌窦肿瘤 鳞状细胞 GST-Π PCNA 预后 

分 类 号：R739.6[医药卫生—肿瘤]