中心体异常、基因不稳定性与肿瘤  

Correlations of Centrosome Abnormality and Genomic Instability to Tumor

作　　者：叶雪(综述)[1] 牛昀[1] 方志沂(审校)[1] 

机构地区：[1]天津医科大学附属肿瘤医院,国家(教育部)乳腺癌防治重点实验室,天津300060

出　　处：《癌症》2005年第10期1290-1292,共3页Chinese Journal of Cancer

基　　金：国家自然科学基金项目(No.30471967)~~

摘　　要：基因不稳定性是人类肿瘤细胞的显著特征,包括细胞倍体改变及一系列染色体异常,而在肿瘤细胞中还发现伴有中心体异常。异常中心体可产生多极纺锤体,使染色体错误分离及分配不平衡,介导染色体不稳定性(CIN)和非整倍体的形成。因此,中心体异常也是肿瘤细胞的普遍特征,并且可能出现在肿瘤发生的早期阶段。Genomic instability, including whole chromosome loss or gain, ploidy change, and a variety of chromosome aberration, is a characteristic of tumor cells. Centrosome abnormality is also found in several kinds of tumors. Abnormal centrosome can cause multipolar spindle formation, chromosome mis-segregation, and unequal distribution, and finally leads to cancers. Therefore, abnormal centrosome is common in tumor cells, and centrosome amplification is probably an early event in the origination and development of cancer.

关 键 词：中心体 基因不稳定性 非整倍体 染色体不稳定性 肿瘤 

分 类 号：R730.231[医药卫生—肿瘤]