通过磁共振成像和神经电生理的影像融合实现癫痫的三维立体定位  

3D stereotaxis for epileptic foci through integrating MR image with neurological electrophysiology data

作　　者：罗敏[1] 彭承琳[1] 王小林[2] 王康[3] 雷文勇[3] 王学建[2] 罗松[3] 吴若秋[4] 伍国锋[4] 

机构地区：[1]重庆大学生物医学工程学院,400044 [2]贵阳医学院附属医院放射科 [3]贵阳医学院附属医院信息网络中心 [4]贵阳医学院附属医院神经电生理中心

出　　处：《中华放射学杂志》2005年第9期978-982,共5页Chinese Journal of Radiology

摘　　要：目的在完善的医学影像存储与传输系统中使用MR影像输出和神经电生理的数据信息进行结合,从而提高对癫痫病的诊断正确率,并将对病人病情正确判断的信息进入放疗设备的三维立体定向放射治疗计划系统.方法使用脑电图工作站对脑电图数据进行回放,同时用Brainvoyager软件对病人的MR检查资料进行重建,在Base 2000中将重建的影像数据与数字脑电图数据坐标结合,生成适合病人头部的三维模型.对临床诊断确诊的12～54岁的癫痫患者30例(其中男18例,女12例)进行磁共振图像与神经电生理信息融合后获得三维立体定位.结果对应的数据信息在三维模型中可呈现病人脑部的真实情况,立体直观地呈现病灶的准确位置.三维立体定向引导下手术切除病灶的成功率大幅度提高,30例病人在发病时间上以每周为单位均有不同程度的减少,其中8例病人术后6个月停止发病,手术获得成功.结论磁共振影像与神经电生理信息的融合,很大程度上提高了癫痫病诊断的整体水平.对于癫痫病的研究及提高手术成功率有着至关重要的意义.Objective To improve the accuracy of the epilepsy diagnoses by integrating MR image from PACS with data from neurological electrophysiology. The integration is also very important for transmiting diagnostic information to 3D TPS of radiotherapy. Methods The electroencephalogram was redisplayed by EEG workstation, while MR image was reconstructed by Brainvoyager software. 3D model of patient brain was built up by combining reconstructed images with electroencephalogram data in Base 2000. 30 epileptic patients （ 18 males and 12 females） with their age ranged from 12 to 54 years were confirmed by using the integrated MR images and the data from neurological electrophysiology and their 3D stereolocating. Results The corresponding data in 3D model could show the real situation of patients＇ brain and visually locate the precise position of the focus. The suddessful rate of 3D guided operation was greatly improved, and the number of epileptic onset was markedly decreased. The epilepsy was stopped for 6 months in 8 of the 30 patients. Conclusion The integration of MR image and information of neurological electrophysiology can improve the diagnostic level for epilepsy, and it is crucial for improving the successful rate of manipulations and the epilepsy analysis.

关 键 词：磁共振成像 电生理学 中枢神经系统 图像处理 计算机辅助 立体定位技术 三维立体定位 神经电生理 癫痫病 影像融合 医学影像存储与传输系统 

分 类 号：R742.1[医药卫生—神经病学与精神病学]