咬合力丧失对大鼠牙周组织中iNOS表达的影响  

Effects of bite force loss on the expression of induced NO synthcse in periodontium

作　　者：李晶[1] 白冰[1] 钟鸣[2] 艾红军[1] 

机构地区：[1]中国医科大学口腔医院修复科,辽宁沈阳110001 [2]中国医科大学口腔医院病理科

出　　处：《中国医科大学学报》2005年第5期440-441,共2页Journal of China Medical University

摘　　要：目的:研究咬合力丧失后诱导型一氧化氮合酶(iNOS)影响牙周组织改建的分子机制。方法:选用W istar大鼠建立咬合力丧失的动物模型,按照拔牙后的各时间段不同随机分8组,采用HE、免疫组化染色法,观察牙周细胞中iNOS的表达。结果:光镜下观察到实验组的牙周组织较正常改建明显。免疫组化染色结果:阳性物质iNOS在牙周膜中的表达实验组较对照组有显著增强,尤其是第2 d和第3周组(P<0.01)。结论:咬合力丧失促使牙周组织中iNOS的表达发生变化,提示iNOS很有可能是影响牙周组织改建的一个重要因素。Objective： To study the effect and molecular mechanism of induced nitric oxide synthase（iNOS） on periodontium remodeling after bite force loss. Methods ： Rat model of bite force loss was established. The rats were divided iuto 8 groups based on the time of bite force loss. The histologic morphology and expression of iNOS were studied by using HE staining and immunohistochemistry method in peridontium cells. Results： In the group of bite force loss, especially in the 2nd-day and 3rd-week group ,the derangenent of periodontal ligament and resorption of alveolar bone were significant, and the expression of iNOS was much more than that in normal group. Conelusion：The iNOS may play an important role in the process of periodontium remodeling.

关 键 词：咬合力丧失 诱导型一氧化氮合酶 牙周组织改建 

分 类 号：R783.4[医药卫生—口腔医学]