胃癌及癌旁组织中无芽胞厌氧菌相关性的研究  

Relevant Research of Non-sporing Anaerobes in Gastric Cancer and Paracancerous Tissue

作　　者：朱晓敏[1] 刘文新[1] 徐静[1] 张博芬[1] 

机构地区：[1]沈阳医学院医学基础部微生物学教研室,辽宁沈阳110034

出　　处：《沈阳医学院学报》2005年第3期152-154,共3页Journal of Shenyang Medical College

摘　　要：目的:在实验研究过程中发现,不同的消化道疾病患者,胃黏膜微生物群的检出率、菌种、数量均有不同,其中胃癌组微生物群改变最明显。方法:对57例胃癌患者的癌组织和癌旁组织进行了无芽胞厌氧菌的检测。结果:胃癌病变的中心部位与癌旁组织的无芽胞厌氧菌的检出情况不同。胃癌组织检出的主要为革兰阳性无芽胞厌氧菌(优杆菌、丙酸杆菌、消化链球菌等),占检出菌株的64.86%(48/74),其中硝酸盐还原实验阳性菌株为59.46%(44/74)。癌旁组织检出的主要为革兰阴性无芽胞厌氧菌(类杆菌、梭杆菌、紫单胞菌、韦荣球菌),占检出细菌的57.14%(24/42),硝酸盐还原实验阳性菌株为16.67%(7/42)。结论:胃癌的病因受多种因素的影响,在胃癌组织中检测到无芽胞厌氧菌对胃癌的形成起到的作用,有待进一步研究。Objective：To found that for different patients with digestive tract disease, the inspective rate of microbial groups in gastric mucosa, types and numbers of bacteria were all different, among which the change of microbial flora in gastric cancer group was the most evident during the experimental study. Methods：In order to understand the relevance of microbe with gastric cancer, non-sporing anaerobes in cancerous and paracancerous tissues of 57 cases having gastric cancer were examined . Results：Inspective condition of non-sporing anaerobes was different between center pathology and paracancerous tissue. In cancerous tissue were mainly Gram-poshive non-sporing anaerobes （ Eubacterium, Propionibacterium, Peptostreptococcus, etc） which occupied 64.86% （48/74） of examined strains and the positive strains of nitrate reduction test were 59.46% （44/74）. In paracancerous tissue were mainly Gram-negative non-sporing anaerobes （Bacteroides, Fusobacterium, Porphyromonas, Veillonella） which occupied 57.14% （24/42） of examined bacteria and the positive strains of nitrate reduction test were 16.67% （7/42）. The pathogenesis of gastric cancer is influenced by various factors. Conclusion：In gastric cancer tissues,tbe functions of non-sporing anaerobes inspected in gastric cancer formation remain to further research.

关 键 词：胃癌 癌旁组织 无芽胞厌氧菌 

分 类 号：R730.231[医药卫生—肿瘤]