p63,34βE12在前列腺良恶性病变中的诊断价值  

Diagnosis value of p63,34βE12 in the prostate benign and malignanic lesions .

作　　者：杨聪颖[1] 陈昊[1] 张昶[1] 王巧[1] 王燕青[1] 

机构地区：[1]江苏连云港市第一人民医院病理科,江苏连云港222002

出　　处：《现代肿瘤医学》2005年第5期604-606,共3页Journal of Modern Oncology

摘　　要：目的研究p63,34βE12在前列腺病变中的诊断价值。方法用S-P免疫组化法对104例不同的前列腺病变进行p63,34βE12标记,观察它们的表达情况。结果p63,34βE12在除前列腺癌(35例)以外的3组良性病变的基底细胞均有阳性表达,但p63的阳性表达率高于34βE12;p63在前列腺癌组织中无表达,而34βE12则有假阳性。结论通过对前列腺不同病变的观察,腺体周围基底细胞是否存在是前列腺良恶性的重要鉴别点。p63,34βE12是基底细胞特异性标记物,而p63更敏感,是诊断前列腺癌的首选抗体。如同时选用p63,34βE12则更为理想。Objective To study the value of p63,34βE12 immunostaining in the diagnosis of prostate lesion. Methods By the S-p immunohistochemical method, we detected the expression of p63,34βE12 in 104 cases of different prostate lesions. Results In 3 groups of benign prostate lesions except the group of prostate cancer, p63, 34βE12 were positive expression in basal cells, but positive rate of p63 was higher than 34βE12 . p63 was negative but 34βas false positive in prostate cancer. Conclusion Through the observation of different prostate lesions, whether the existence of basal cells of glands or not is an important discriminate of prostate benign and malignant lesions, p63,34βE12 were basal cell - specific marker, but p63 is more sensitive and is the first antibody of prostate cancer. It would be more farorable if the p63,34βE12 are applied at the same time.

关 键 词：前列腺病变 鉴别诊断 基底细胞 P63 34ΒE12 免疫组化 

分 类 号：R737.25[医药卫生—肿瘤]