艾本治疗恶性肿瘤骨转移的临床研究  

Clinical study on the effect of Aiben in treatment of malignant bone metastasis.

作　　者：范开席[1] 汪梅荣[1] 周正波[1] 胡德荣[1] 张燕[1] 郭其森[1] 孙雅红[1] 冯斌[1] 

机构地区：[1]山东省肿瘤防治研究院内二科,山东济南250117

出　　处：《现代肿瘤医学》2005年第5期667-668,共2页Journal of Modern Oncology

摘　　要：目的观察艾本对恶性肿瘤骨转移疼痛和转移灶的治疗效果。方法对恶性肿瘤骨转移者静脉应用艾本4mg,每月1次,1个月为1周期,至少2周期后评价疗效及不良反应,疗效评价指标包括止痛效果、KPS评分的变化和转移灶的改变情况。结果疼痛完全缓解14例,有效31例,无效7例,有效率86.54%;KPS评分提高的中位数为10;骨转移灶CR2例,PR9例,MR12例,总有效率44.23%;不良反应为发热、恶心及腹胀,发生率低。结论艾本对骨转移引起的疼痛有良好的止痛效果,对转移灶有较好的治疗作用,副作用少,值得临床应用。Objective To observe the efficacy of Aiben to treat metastatic bone and to relieve pain. Methods Aiben 4 mg was given by infusion, the treatment was repeated at 1 month intervals, the effect and toxicity were evaluated after at least 2 cycles . The evaluated target included the relieving pain.the change of KPS and the change of metastatic focus. Results Complete relief of pain was in 14 patients, partrial relief 31 patients, no effect 7 patients with a total effective rate of 86.54% ; KPS rised median 10; Among these patients with metastatic bone ,complete response 2, partial response 9, miscro response 12, the total effective rate was 44.23% ; The toxicity reactions were fever. nausea and abdominal distention, but the rate was low. Conclusion Aiben is effective to relieve the pain of metastatic bone cancer and is effective to treat metastatic focus, the side effect can be tolerated . It can be used in clinic.

关 键 词：艾本 止痛 恶性肿瘤 骨转移 

分 类 号：R738.1[医药卫生—肿瘤]