膀胱癌中S-100蛋白、增殖细胞核抗原表达的意义  

Exploration on the significance of the bladder transitional cell carcinoma S-100 and PCNA expression

作　　者：李曼红[1] 邱前程[1] 蔡聪[2] 

机构地区：[1]汕头大学医学院第一附属医院病理科,广东汕头515041 [2]汕头大学医学院第一附属医院泌尿外科,广东汕头515041

出　　处：《中国基层医药》2005年第9期1143-1144,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省医学科研基金立项课题(B2002080)

摘　　要：目的探讨膀胱移行细胞癌中S100蛋白、增殖细胞核抗原(PCNA)的表达及其意义。方法采用免疫组化SP法检测癌间质中树突状细胞(DC)和癌细胞PCNA。结果31例膀胱移行细胞癌中不同病理分级的肿瘤,DC表达和PCNA的表达均具明显差异(P<0.05)。结论膀胱移行细胞癌中PCNA的表达随肿瘤病理分级升高而增强,DC的表达随膀胱移行细胞癌病理分级升高而下降。Objective To explore the S-100 and PCNA expression and significance in bladder cancer. Methods SP method of immunohistochemistry was used to examine the dendritic cell（DC） and proliferating cell nuclear antigen（PCNA）. Results The DC and PCNA expressions were different obviously in 31 cases of bladder cancer（P 〈 0.05）. Conclusion The PCNA expression increases with the rise of pathologic grade of bladder cancer, while the DC expression decreases at the same time.

关 键 词：膀胱肿瘤 树突细胞 增殖细胞核抗原 免疫组织化学 增殖细胞核抗原(PCNA) S-100蛋白 核抗原表达 膀胱移行细胞癌 肿瘤病理分级 膀胱癌 免疫组化SP法 树突状细胞 其意义 

分 类 号：R737.14[医药卫生—肿瘤]