立体定向放射治疗非小细胞肺癌疗效观察  

Stereotatic radiotherapy non-small cell lung cancer

作　　者：王文高[1] 王琍[1] 魏子祥[1] 王多为[1] 江典模 

机构地区：[1]淮南东方医院集团肿瘤医院放疗中心,安徽淮南232035

出　　处：《中国基层医药》2005年第9期1181-1182,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的研究立体定向放射治疗非小细胞肺癌的疗效。方法107例非小细胞肺癌由立体定向治疗计划系统设计放射治疗计划,剂量体积直方图(DVH)评价和优化放射治疗计划,计划照射剂量为60～75Gy(中位剂量68Gy),每次2.2～3.0Gy,每天1次,每周5d,由美国瓦里安CL2100加速器照射,射野为固定野和非共面野或者大旋转弧。按照美国放射治疗协作组(RTOG)和WHO标准观察急性放射反应和疗效。结果疗效(CR+PR)为88%(94/107),(NC+PD)即无效病例为12%(13/107)。1～3年生存率分别为85.78%、49.02%、23.88%。结论立体定向放射治疗采用大弧旋转+固定野照射,方法可行,有较好的疗效,早期并发症较低,能为患者耐受。Objective To evaluate the feasibility of stereotatic radiation therapy non-small cell lung cancer. Methods Among 107 NSCLC patients,radio-therapy was designed by the U. S Topslane corporation stereotatic radiotherapy planning system and dose volume histograhpy（DVH） was used to verify and optimize the radiation plan. The total irradiation dose,ranging from 60Gy to 75Gy, was delivered at 2.2- 3.0Gy once daily, 5 days per week, fields of beam were large rotation angle and non-moving angle by varian CL2100 accelerator the immediate responses and acute side-effects were evaluated according to the WHO and RTOG criterion system. Results All 107 patients completed their radiotherapy. The median radiation therapy dose to the gross tumor volume（GTV） was 68Gy（60～75Gy）. The overall immediate responses rate（CR ＋ PR） was 88 % （94/107）. The 1,2,3-year survival rates were ： 85.78 % ,49.02 % ,23.88 %. Conclusion Stereotatic radiotherapy can be considered as an effective and feasible approach to treat NSCLC with good responses and without any early serious complications. Long -term survival and possible specific injury shall await further study.

关 键 词：癌 非小细胞肺 立体定位技术 放射疗法 立体定向放射治疗 非小细胞肺癌 疗效观察 剂量体积直方图(DVH) 放射治疗计划 急性放射反应 照射剂量 大弧旋转 WHO标准 

分 类 号：R734.2[医药卫生—肿瘤]