泮托拉唑治疗上消化道出血疗效观察  

The effects of pantoprazole sodium for injection on patients with upper gastrointestinal bleeding

作　　者：陈勇[1] 

机构地区：[1]福建省立医院消化科,福建福州350001

出　　处：《中国基层医药》2005年第9期1226-1227,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的评价注射用泮托拉唑钠对非曲张静脉上消化道出血的疗效和安全性。方法选择上消化道出血患者80例,泮托拉唑组50例,法莫替丁组30例,分别用泮托拉唑40mg或法莫替丁20mg加入0.9%生理盐水100ml内,静脉滴注(30～60min),每日2次,共5d。观察生命体征和出血情况,并记录不良反应。结果治疗后3d内泮托拉唑组45例(90%)止血,法莫替丁组13例(43.3%)止血,4～5d内止血分别为4例(8.0%)和10例(33.3%)。止血显效率泮托拉唑组非常显著高于法莫替丁组(P<0.01),治疗总有效率泮托拉唑组显著高于法莫替丁组(P<0.05)。两组不良反应发生率分别2%和20%,差异有显著意义(P<0.05)。结论泮托拉唑粉针剂是治疗非曲张静脉上消化道出血安全有效的药物。Objective To evaluate the effects and safety of pantoprazole sodium for injection on patients with upper gastrointestinal bleeding. Methods Eighty patients with nonvariceal upper gastrointestinal bleeding were as signed to two groups. Fifty patients were in the group of pantoprazole. Treatment schemes： either pantoprazole 40mg or famotidine 20mg were added into 100ml 0.9% NaCl respectively and then infused intravenously at every twice day and standing five day. The clinical signs of the patients including the amout of bleeding were observed and the side effects were recorded. Results After the treatment, the obvious effective rate in three days and total effective rate were 90.0 % and 98.0% in pantoprazole group and 43.3 % and 76.7% in famotidine group, the former was much higher than the letter（ P 〈 0.05）, especially the obvious effective （ P 〈 0.01 ）. The rates of side effects were 2. 0 % in pantoprazole group and 20 % in famotidine group,improved significantly in both groups（ P 〈 0.05）. Conclusion Pantoprazole sodium for injection is an effective and safe drug for the non-variceal upper gastrointestinal bleeding.

关 键 词：泮托拉唑 消化性溃疡出血 药物疗法 非曲张静脉上消化道出血 注射用泮托拉唑钠 疗效观察 治疗后 不良反应发生率 泮托拉唑粉针剂 法莫替丁 出血患者 生理盐水 

分 类 号：R573.2[医药卫生—消化系统] R975.6[医药卫生—内科学]