电化学治疗中晚期肝癌的临床观察  

Clinical results of middle and late stage liver cancer treated with electrochemical therapy

作　　者：辛育龄[1] 彭泽斌[1] 

机构地区：[1]北京中日友好医院

出　　处：《实用肿瘤杂志》1996年第2期58-62,共5页Journal of Practical Oncology

摘　　要：１９８７年至１９９１年应用电化学疗法治疗中晚期肝癌１６５例，其中原发癌１２５例，转移癌４０例。临床分期属Ⅱ期２６，Ⅲ期８９例，Ⅳ期５０例。位于右叶内８３例，左叶内５６例，左右叶均有２６例。肿瘤直径大小：４．０～６．０ｃｍ２６例；６．１～７．０ｃｍ５８例；７．１～８．０ｃｍ５１例；８．１～９．０ｃｍ３２例；９．１～１０．０ｃｍ２５例；＞１０ｃｍ１９例。在Ｂ超或ＣＴ定位引导下插入电极针，阴极和阳极相互搭配，按肿瘤大小插入电极根数，电极间距２～２．５ｃｍ。电压６～８Ｖ，电流６０～８０ｍＡ，电量每厘米给１００Ｃ。治疗后观察３个月，按国际标准评价疗效：ＣＲ３６例（２１．８％），ＰＲ６５例（３９．３％），ＮＣ３５例（２１．２％），ＰＤ２９例（１７．６％）。经１～５随访，其１、２、３、４、５年生存率分别为５６．９％、２９．６％、１３．９％、１０．３％、５．４％。电化学疗法与介入疗法并用，能提高肝癌治疗效果。From 1987 to 1991, 165 cases of middle and late stage liver cancer received electrochemical therapy(ECT). There were 108 male and 59 female patients wiht the age of 33 to 78 yeare. 125 were primary liver cancer and 40 metastatic diseases. In this group. 26 cases were diagnosed as stage Ⅱ, and 89 in stage Ⅲ, 50 in stage Ⅳ. 83 cases of tumors were located in the right lobe of liverand 56in the left lobe. Other 26 cases were multiple lesion in both lobes. The number of cases in tumor diameter of 4.0～6.0cm, 6.1～7.0cm, 7.1～8.0cm, 8.1～9.0cm, >10.0cm, were 26、58、51、32、25 and 19 cases, respectively. Under the guide of ultrasonography and CT, electrodes were inserted to tumor mass, The number of electrodes was determined by the tumor size. The distance between two electrodes was 2 to 2.5cm. Voltage used was 6.0～8. 0V and current 60～80 mA. Electric quantity was 100 C for per 1.0 cm diameter of tumor mass. All patients were followed up for three months after ECT. According to UICC criteria, there were 36(21.8%) in CR, 65(39.3%) in PR, 35(21.2%) in NC and 29(17. 6%) in PD. the 1、2、3、4 and 5-year survival rates were 56.9%、29.6%、13.9%、10.3% and 5.4% , respectively.

关 键 词：肝肿瘤 电化学疗法 

分 类 号：R735.705[医药卫生—肿瘤]