手性二胺修饰的Ru/γ-Al_2O_3催化剂催化芳香酮不对称加氢  

Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by Chiral Diamine Modified Ru/γ-Al_2O_3

作　　者：熊伟[1] 黄艳轶[1] 陈华[1] 李贤均[1] 

机构地区：[1]四川大学化学学院有机金属络合催化研究所教育部绿色化学及技术重点实验室

出　　处：《化学学报》2005年第20期1927-1930,共4页Acta Chimica Sinica

摘　　要：研究了用手性修饰剂(1S,2S)-(-)-1,2-二苯基乙二胺修饰的负载型钌催化剂(Ru/γ-Al2O3)催化芳香酮的不对称加氢反应,在KOH的异丙醇溶液中,10～20℃,=5MPa条件下,芳香酮及其衍生物加氢产物的ee值达79.5%～85.0%,2-乙酰基噻吩加氢产物的ee值可达86.2%.此催化剂制备简单,容易与产物分离,重复使用4次,对映选择性基本保持不变.Asymmetric hydrogenation of acetophenone and its derivatives, acetylpyridine, five-membered heterocyclic ketones catalyzed by [1S,2S-（—）-1,2-diphenyl-1,2-ethylenediamine] （S,S-DPEN） modified Ru/y-Al2O3 catalyst was investigated. Under the reaction conditions of 10～20 ℃, p=5.0 MPa in KOH/i-PrOH solution, the ee value of aromatic alcohols produced from hydrogenation of acetophenone and its derivative could reach 79.5%～85.0%. The ee value of the hydrogenation product of 2-acetothiophene was 86.2% at 20 ℃ and p=7 MPa. The catalyst was stable in air and could be easily separated from the product and reused several times without remarkable change of the enantioselectivity.

关 键 词：钌 (1S 2S)-(—)-1 2-二苯基乙二胺 芳香酮 不对称加氢 对映选择性 负载型钌催化剂 胺修饰 手性 RU 加氢产物 

分 类 号：O643.32[理学—物理化学]