脑梗死患者超声配合激光治疗前、后血浆GMP-140和vWF水平变化及其临床意义  

Changes of plasma GMP-140 and vWF in patients with cerebral infarction before and after ultrasonic therapy

作　　者：阳小云[1] 朱育昌[2] 侯敢[3] 黄迪南[3] 伍洲亮[1] 

机构地区：[1]广东医学院附属医院康复理疗科,湛江524001 [2]广东医学院附属医院神经内科,湛江524001 [3]广东医学院生化教研室,湛江524001

出　　处：《中华物理医学与康复杂志》2005年第10期622-624,共3页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：湛江市科委攻关项目(No.200370)4

摘　　要：目的探讨超声治疗脑梗死患者血浆α颗粒膜蛋白140(GMP140)和血管性血友病因子(vWF)含量变化及临床意义。方法选用未使用抗血小板药物治疗的脑梗死患者进行超声治疗(常规药物+超声+激光),用ELISA双抗体夹心法测定治疗前、后血浆GMP140和vWF的含量。结果脑梗死患者治疗前血浆GMP140和vWF水平较正常对照组高(P<0.05),且患者治疗前血浆GMP140和vWF呈显著正相关(r=0.47,P<0.01);超声治疗组治疗前、后比较,GMP140和vWF降低,差异有统计学意义(P<0.05),并接近正常对照组;超声治疗组较药物治疗组治疗后GMP140和vWF降低更明显,但差异无统计学意义(P>0.05);超声治疗对神经功能缺损程度的治疗效果优于单纯药物治疗组(P<0.05)。结论脑梗死患者体内存在血小板活化,GMP140和vWF可能共同参与了脑梗死发生发展过程,超声治疗脑梗死的机制可能与GMP140和vWF等多种因素有关。Objective To study the changes of plasma granule membrane protein-140 （GMP-140） and yon Willebrand factor（ vWF） in patients with cerebral infarction caused by ultrasonic therapy. Methods Plasma GMP- 140 and vWF in patients with cerebral infarction without any antiplatelet treatment but ultrasonic therapy （routine drug therapy plus ultrasonic therapy and laser） were measured by double antibodies ELISA, respectively. Results The levels of both plasma GMP-140 and vWF in groups with cerebral infarction before therapy were significantly higher than that in control group （ P 〈 0.05 ）. Moreover, plasma GMP-140 level was positively correlated with plasma vWF（r =0.47, P 〈 0.01 ） before therapy. But they both decreased after ultrasonic therapy（ P 〈 0.05 ） and were close to normal control. The levels of both plasma GMP-140 and vWF in groups with cerebral infarction after ultrasonic therapy were much lower than that in drug（only） group, but the difference was not statistically significant（P 〉 0.05）. The curative effect to neurologic impairment in ultrasonic therapy group was better than that in the drugs （ on- ly） group（P 〈0.05）. Conclusion The findings indicated that there is elevation of platelet activation in patients with cerebral infarction. It was suggested that GMP-140 and vWF were associated with pathophysiologic progress of cerebral infarction. And the mechanism of ultrasonic therapy in cerebral infarction may relate to both effects of GMP- 140 and vWF.

关 键 词：超声治疗 脑梗死 膜蛋白类 血管性血友病因子 血浆GMP-140 脑梗死患者 临床意义 水平变化 VWF 治疗前 

分 类 号：R743.33[医药卫生—神经病学与精神病学]