宫颈病变DNA倍体分析及临床意义  

The assessment and clinical significance of DNA ploidy analysis in cervical lesions

作　　者：宋改环[1] 朱宇[1] 朱凤全[1] 田庚[1] 

机构地区：[1]吉林大学第二医院,130041

出　　处：《中国妇幼保健》2005年第20期2657-2659,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨DNA异倍体与宫颈上皮内瘤样病变及宫颈癌之间的关系。方法:宫颈鳞癌40例,宫颈上皮内瘤样病变81例(C INⅠ-Ⅱ级42例,C IN-Ⅲ级39例),慢性宫颈炎30例行流式细胞仪DNA倍体分析。正常宫颈组20例作为对照。结果:C INⅠ-Ⅱ级、C IN-Ⅲ级、宫颈癌组DNA异倍体率呈上升趋势,且各组间有显著性差异(P<0.05,P<0.01),C INⅠ-Ⅱ级、C IN-Ⅲ级DNA异倍体D I值与宫颈癌组比较有显著性差异(P<0.001),C INⅠ-Ⅱ级、C IN-Ⅲ级D I值比较有显著性差异(P<0.05)。结论:应用FCM进行DNA倍体分析对于宫颈癌的诊断、预后判断及上皮内瘤样病变恶性倾向的判断、治疗及随访有着非常积极的临床意义。Objective： To discuss the relationship of DNA aneup in group of fetus that were ill pregnanted loid and cervical intraepithelial neoplasia, cervical cancer. Methods： 40 cases cervical squamous carcinoma , 81 cases cervical intraepithelial neoplasia （42 cases CIN Ⅰ-Ⅱ, 39 cases CIN Ⅲ ） and 30 cases chronic cervicitis were subjected to DNA ploidy analysis and the normal cervical tissues were control groups. Results： An increasing trend of DNA aneuploidy and DI value in DNA aneuploidy cell was observed from CIN Ⅰ-Ⅱ to CIN Ⅲ to cervical cancer. Conclusion： The significance of DNA ploidy measurement is related to diagnosis of cervical cancer , prediction of patients＇prognosis and treatment , DNA ploidy also act as a high risk indicator in cervical intraepithelial neopIasia.

关 键 词：流式细胞仪 DNA倍体 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]