联立方程组测定肤炎霜中盐酸赛庚啶的含量  

Content Determination of Cyproheptadine Hydrochloride in Fuyan Cream by Simultaneous Equations

作　　者：陈元俊[1] 周金生[1] 卢玉兰[1] 丁川[1] 连劲龙[1] 

机构地区：[1]解放军第180医院,泉州市362000

出　　处：《中国药房》2005年第20期1581-1582,共2页China Pharmacy

摘　　要：目的:建立肤炎霜中盐酸赛庚啶的含量测定方法.方法:采用紫外分光光度法,对本品不经分离提取,将其中多组分组成的辅料假定为与主药盐酸赛庚啶并存的另一组分,均分别于286、258nm波长处测定吸收度,然后对所得结果进行线性回归并联立方程组,计算含量.结果:盐酸赛庚啶、辅料检测浓度分别在2.52～25.2、2.5022～25.022μg/ml范围内线性关系良好,盐酸赛庚啶平均回收率为98.61%(RSD=1.08%).结论:本方法简便、快速、重现性好、结果可靠,适合该制剂的快速检测.OBJECTIVE： To establish a method for content determination of cyproheptadine hydrochloride in fuyan cream.METHODS： Uhraviolet spectophotometry was applied to determine the contents of cyprohepatadinc hydrochloride as well as its adjuvant as two coexisting components without isolation and extraction,the wavelengths were 286nm and 258nm respectively,linear regression and simultaneous equations were used to analyze the results. RESULTS： Cyproheptadine hydrochloridc and its adjuvant showed good linear relationship in the range of 2.52～25.2 and 2.5 022～25.022μg/ ml respectively, the average recovery of cyprohcptadine hydrochloride was 98.61% （RSD= 1.08% ） .CONCLUSION： The present method is simple, convenient ,reproducible and reliable,which is suitable for rapid determination for fuyan cream.

关 键 词：紫外分光光度法 肤炎霜 盐酸赛庚啶 联立方程组 含量 

分 类 号：R927.2[医药卫生—药学]