血清NO、IL-6、TNF-α与高血压性脑出血早期头痛的关系  

CORRELATION OF SERUM NITRIC OXIDE , IL-6 AND TNF-α LEVELS WITH HEADACHE RELATED TO HYPERTENSIVE INTRACEREBRAL HEMORRHAGE

作　　者：李新立[1] 夏强[1] 徐林新[1] 刘群才[1] 徐明义[1] 冀凌霄[1] 

机构地区：[1]中国人民解放军第159医院神经内科,河南驻马店463008

出　　处：《中国疼痛医学杂志》2005年第4期204-206,共3页Chinese Journal of Pain Medicine

摘　　要：目的:探讨血清一氧化氮(NO)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)在高血压性脑出血(HIH)病人头痛条件下的变化。方法:分为四组进行观察,其中HIH合并头痛者(头痛组)31例,HIH无头痛者(对照组)30例,健康人(正常组)30例,单纯偏头痛者(偏头痛组)30例。测定血清中NO含量用硝酸酶还原法,测定IL-6采用ELISA法,测定TNF-α用放射免疫法。结果:血清NO、IL-6、TNF-α含量比较,头痛组、对照组、偏头痛组较正常组均明显升高,但头痛组较对照组及偏头痛组升高更显著。出血量的多少与血清NO、IL-6、TNF-α含量无明显关系。结论:HIH病人早期血清中NO、IL-6、TNF-α显著升高,合并头痛者升高更显著,但与出血量的多少无关。Objective：To determine whether serum nitric oxide （NO）, IL-6 and TNF-α levels correlated with hypertensive intracerebral hemorrhage（HIH） combining headache. Methods： Four groups including HIH combining headache （ n = 31 ）, HIH without headache （ n = 30 ）, migraine group （ n = 30 ） and healthy group （n = 30） were observed. Using nitric acid enzyme deoxidization , enzyme linked immune absorption and radioimmunoassay, the serum levels of NO, IL-6 and TNF-α were determined respectively. Results ： Compared with the healthy group, the serum NO, IL-6 and TNF-α levels of the other three groups were significantly increased ; in addition, those of HIH combining headache group was significantly higher than HIH headache-free and migraine group. There were no significant relationship between the amount of hemorrhage and the serum NO, IL-6 and TNF-α levels. Conclusion： Serum NO, IL-6 and TNF-α levels in HIH patients are significantly elevated, especially under the condition of headache, but is not associated with the amount of hemorrhage.

关 键 词：高血压性脑出血 头痛 一氧化氮 白介素-15 肿瘤坏死因子-Α 肿瘤坏死因子-α(TNF-α) IL-6 血清NO 偏头痛 早期血清 

分 类 号：R743.34[医药卫生—神经病学与精神病学]