胃肠道肿瘤患者外周血中SS,TNF-α,IL-6和sIL-2R检测的临床意义  

Clinical significance and assay of peripheral blood somatostatin,TNF-α,IL-6,sIL-2R in patients with gastrointestinal cancer

作　　者：卢锋[1] 乔玲[1] 万菊萍[2] 

机构地区：[1]河南大学医学院细胞分子免疫实验室,河南开封475001 [2]河南大学附属淮河医院内科,河南开封475001

出　　处：《第四军医大学学报》2005年第19期1795-1796,共2页Journal of the Fourth Military Medical University

摘　　要：目的:观察胃肠道肿瘤患者外周血生长抑素(SS)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、可溶性白介素-2受体(sIL-2R)表达水平的变化.方法:正常对照组23例,胃癌组37例,结肠癌组23例,直肠癌组29例.放射免疫法(R IA)检测SS,ELISA法检测TNF-,αIL-6和sIL-2R水平.结果:与对照组相比,胃癌组、结肠癌组、直肠癌组SS水平明显降低,而血清中IL-6,sIL-2R水平则明显升高(P<0.05),且后两者在三种类型的胃肠道肿瘤间显示组间差(P<0.05);结肠癌组、直肠癌组TNF-α与对照组及胃癌组间差别有显著性(P<0.05).结论:检测血液中SS,TNF-,αIL-6和sIL-2R对胃肠道肿瘤的诊断有一定的意义.AIM： To observe the changes of peripheral blood somatostatin （ SS）, tumor necrosis factor-α（ TNF-α）, interleukin-6 （IL-6） and soluble interleukin-2 receptor （slL-2R） levels in patients with gastrointestinal cancer. METHODS： The subjects were divided into 4 groups： 23 cases in normal control group, 37 patients in gastric cancer group, 23 patients in colon carcinoma group and 29 patients in rectal cancer group. The levels of TNF-α, IL-6 and slL- 2R were assayed with ELISA and SS was assayed with RIA. RESULTS, Compared with that in control group, the level of SS decreased significantly in gastric cancer group, colon cancer group and rectal cancer group, but the serum levels of IL-6 and slL-2R increased remarkably. The levels of IL-6 and slL-2R were significantly different in the 3 types of gastrointestinal cancer （ P 〈 0.05）. Significant difference was found in the level of TNF-α when control group and gastric cancer group were compared with colon and rectal cancer groups （ P 〈 0.05）. CONCLUSION： The detection of the changes of peripheral blood SS, TNF-α, IL-6 and slL-2R is of some clinical significance in the diagnosis and differentiation of patients with gastrointestinal cancer.

关 键 词：肿瘤 胃肠道 生长抑素 肿瘤坏死因子 白介素 受体 

分 类 号：R730.3[医药卫生—肿瘤]