AnnexinⅡ在已分化人表皮角质形成细胞中表达的研究  

Study on annexinⅡ expression in differentiation of human epidermal keratinocyte

作　　者：李习玲[1] 连小华[1] 杨力[2] 杨恬[1] 

机构地区：[1]第三军医大学基础医学部细胞生物学教研室,重庆400038 [2]重庆大学生物工程学院,重庆400044

出　　处：《第三军医大学学报》2005年第17期1793-1795,共3页Journal of Third Military Medical University

基　　金：国家自然科学基金资助项目(30371383;30270671)~~

摘　　要：目的探讨annexinⅡ在已分化人表皮角质形成细胞(keratinocyte,KC)中的表达。方法采用免疫组织化学(immunoh istochem istry,IHC)技术检测早、中、晚期人胚胎表皮KC及成人表皮KC中annexinⅡ蛋白的表达。结果①annexinⅡ在人胚胎期表皮KC中的表达随胚胎的发育逐渐增强,在成人期表皮KC中的表达明显高于胚胎期。②annexinⅡ呈胞膜方式表达,主要分布于基底上层的分化KC中。结论annexinⅡ可能参与表皮KC分化的调控。Objective To explore the annexin Ⅱ expression in the differentiation of human epidermal keratinocytes. Methods Immunohistochemistry was used to detect annexin Ⅱ expression in early, middle, late human embryonic skin and adult skin, respectively. Results The expression of annexin Ⅱ in embryonic epidermis was significantly increased with the development of embryo and annexin Ⅱ expressed much higher in adult epidermis than in embryonic epidermis. Annexin Ⅱ localized in the membrane of keratinocyte, mainly in suprabasal, the more differentiated layers of the epidermis. Conclusion Annexin Ⅱ may be involved in regulating the differentiation of human epidermal keratinocytes.

关 键 词：ANNEXIN Ⅱ 组织型纤溶酶原激活剂 角质形成细胞 分化 人胚胎 成人 

分 类 号：R322.991[医药卫生—人体解剖和组织胚胎学] R392.11[医药卫生—基础医学]