模拟人体胃肠道环境对儿茶素稳定性的影响  

Stability of Tea Catechin in the Artificial Simulation Gastric Juices and Artificial Simulation Intestinal Juice

作　　者：何小解[1] 卢向阳[1] 易著文[2] 方俊[1] 田云[1] 党西强[2] 莫双红[2] 

机构地区：[1]湖南农业大学生化与发酵工程实验室,湖南长沙410128 [2]中南大学湘雅二医院小儿肾脏病研究室,湖南长沙410011

出　　处：《湖南农业大学学报（自然科学版）》2005年第5期527-529,共3页Journal of Hunan Agricultural University(Natural Sciences)

基　　金：湖南省自然科学基金资助项目(02JJXY3020);湖南省教育厅重点资助项目(02A015)

摘　　要：为研究模拟人体胃肠道环境对儿茶素稳定性的影响,利用高压液相色谱技术测定了不同时点儿茶素在不同pH溶液及人工模拟体胃液与肠液中的含量.结果表明,儿茶素在pH5.8时最稳定,人工模拟胃液对儿茶素具有较强的破坏力,而人工模拟肠液对儿茶素的稳定性影响相对较小;胃蛋白酶、胰蛋白酶以及缓冲溶液中盐类物质并不影响儿茶素的稳定性.To study the stability of tea catechin in the artificial simulation gastric juices and artificial simulation intestinal juice, the authors applied liquid chromatography to examine the stability in the environment of vary pH and simulation stomach and intestines way. Results showed stability of tea catechin were best in pH5.8, with tea catechin comparative largeiy destructed in the artificial simulation gastric juices. However, it was comparatively stable in the artificial simulation intestinal juice, and tea catechin wasn＇t affected by the saline material of pepsin, trypsin and buffer solution.

关 键 词：儿茶素 人工模拟胃液 人工模拟肠液 

分 类 号：R965.1[医药卫生—药理学]