原位钴配合物催化苄基双羰化反应  

A Study on the In-situ Double Carbonylation of Benzyl Catalyzed by Cobalt Complex

作　　者：朱康玲[1] 李美清[1] 李琳[1] 吴方勇[1] 李光兴[1] 

机构地区：[1]华中科技大学化学系,湖北武汉430074

出　　处：《分子催化》2005年第5期403-407,共5页Journal of Molecular Catalysis(China)

摘　　要：The double carbonylation of benzyl chloride catalyzed by cobalt complex is studied.The catalytic system are composed of cobaltous chloride and pyrazinyl ligands or pyridyl ligands,respectively.Among pyridyl ligands,Pyridine-2-carboxylate anionPyca^- has the highest catalysis activity with the yield of phenylpyruvic acidPPA 69.2%.When there is an electron attractive group on the pyridine ring of pyridine monocarboxylic acid,the products are PPA,and with the group’ electron attractivity increasing,the catalysis activity of the catalytic system is decreased.When ligands are pyrazinyl anions,the products are β-benzyl-α-phenylpyruvic acidBPPA.Thereinto,Pyrazine-2-carboxylate anionPzca^- has the highest catalysis activity with the yield of β-benzyl-α-phenylpyruvic acidBPPA 56.8%.The catalysis systems with pyrazinyl or pyridyl acids have not catalysis activity at all.When ligand is the mixture of nPzca^-∶nPyca^-=1∶1,BPPA yield reaches 72.7%,and the reaction rate is between two ligands to be separately used.These experiment results are discussed in detail.The double carbonylation of benzyl chloride catalyzed by cobalt complex is studied. The catalytic system are composed of cobaltous chloride and pyrazinyl ligands or pyridyl ligands, respectively. Among pyridyl ligands, Pyridine-2-carboxylate anion （Pyca^-） has the highest catalysis activity with the yield of pbenylpyruvic acid （PPA） 69.2%. When there is an electron attractive group on the pyridine ring of pyridine monocarboxylic acid, the products are PPA, and with the group＇electron attractivity increasing, the catalysis activity of the catalytic system is decreased. When ligands are pyrazinyl anions, the products are β-benzyl-α-phenylpyruvic acid （BPPA）. Thereinto, Pyrazine-2-carboxylate anion （Pzca^-） has the highest catalysis activity with the yield of β-benzyl-α-pbenylpyruvic acid （BPPA） 56.8%. The catalysis systems with pyrazinyl or pyridyl acids have not catalysis activity at all. When ligand is the mixture of n（Pzca^-）： n（Pyca^-） = 1： 1, BPPA yield reaches 72.7%, and the reaction rate is between two ligands to be separately used. These experiment results are discussed in detail.

关 键 词：双羰化 β-苄基-α-苯丙酮酸 α-苯丙酮酸 毗嗪 毗啶 氯苄 

分 类 号：O643.32[理学—物理化学]