雷贝拉唑三联疗法根除93例Hp的临床疗效观察  

Therapeutic Efficacy of Rebeprazole in 93 Cases of Helicobacter Pylori Infection

作　　者：朱水山[1] 张弘英[1] 余戎[1] 文艺[1] 杜芳腾[1] 

机构地区：[1]江西医学院第二附属医院,江西南昌330006

出　　处：《实用临床医学（江西）》2005年第10期26-27,共2页Practical Clinical Medicine

摘　　要：目的:观察雷贝拉唑联合克拉霉素和阿莫西林根除幽门螺杆菌(Hp)的临床疗效.方法:将186例Hp阳性的消化性溃疡及慢性胃炎患者随机分为雷贝拉唑治疗组和奥美拉唑对照组,两组联合的抗菌药均为克拉霉素和阿莫西林,疗程1周.各组在治疗前1周内和治疗后4～8周分别检测Hp感染情况,并观察溃疡的愈合情况.结果:雷贝拉唑治疗组Hp根除率(96.8%)明显高于奥美拉唑对照组(89.2%)(P<0.05),两组溃疡愈合率比较无显著性差异(P>0.05).结论:雷贝拉唑联合克拉霉素和阿莫西林是根除Hp比较有效的治疗方案,值得临床进一步推广应用.Objective： To evaluate the efficacy of rebeprazole--based triple therapy regimen contained elarithromycin and amoxicillin for the eradication of Helicobaeter pylori （Hp） infection. Methods：One hundred and eighty six patients with Hp infection accompanied by peptic ulcer or chronical gastritis were randomly divided into rebeprazole-group and omeprazole-group, and the therapy course was a week. The eradication rates of Hp and the healing rates of peptic ulcer were evaluated in 4-8 weeks after completion of treatment. Results： The eradication rate of Hp in rebeprazole-group （96.8%） was significantly higher than that in Omeprazole-group （89.2%） （P〈0.05）, and the healing rates of peptic ulcer were no statistically significant difference in two groups. Conclusion： Rebeprazole- based triple therapy regimen contained clarithromycin and amoxicillin is very efficient for the eradication of Hpol.

关 键 词：HP感染 雷贝拉唑 奥美拉唑 克拉霉素 阿莫西林 

分 类 号：R573.3[医药卫生—消化系统]