阿托伐他汀钙与β-环糊精相互作用的研究及应用  

Studies on Interaction of Atorvastatin Calcium with β-Cyclodextrin and Its Application

作　　者：董社英[1] 黄廷林 郑建斌[3] 高鸿[3] 

机构地区：[1]西安建筑科技大学理学院 [2]环境与市政工程学院,西安710055 [3]西北大学电分析化学研究所,西安710069

出　　处：《高等学校化学学报》2005年第11期2023-2026,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20275030);陕西省教育厅专项科研基金(批准号:05JK228)资助

摘　　要：采用线性扫描伏安法和循环伏安法并结合紫外分光光度法研究了新型抗血脂紊乱药物阿托伐他汀钙(AC)与β-环糊精(-βCD)的相互作用.探讨了-βCD对AC的峰电流及AC对-βCD吸附峰电流的影响,测得在0.06 mol/L KH2PO4-Na2HPO4(pH=7.17)缓冲溶液中,AC与-βCD包结比为1∶1,用电流法测得包结物的形成常数为9.09×104L/mol.根据碱性介质条件下β-CD分子与AC形成包结物而使β-CD吸附峰电流减小的特性,建立了一种利用β-CD间接测定AC的伏安方法.Abstract The interaction of Atorvastatin calcium（AC） with β-cyclodextrin（β-CD） was studied by means of linear scan voltammetry, cyclic voltammetry and UV spectra. The experimental results show that electroactive molecule AC was complexed with β-CD to form 1 ： 1 inclusion complex in 0. 06 mol/L KH2PO4-Na2HPO4 （ pH = 7.17） buffer solution. The inclusion constant was calculated to be 9.09 × 10^4 L/mol by electric current method. In addition, an inclusion complex between β-CD and AC in NaOH solution was formed, which induced the decrease of adsorptive peak current of β-CD. Based on the characteristics, an indirect voltammetry for AC determination was found, and this method was more sensitive than the direct method.

关 键 词：阿托伐他汀钙(AC) β-环糊精(β-CD) 相互作用 包结物 

分 类 号：O657.14[理学—分析化学]