肝素化聚醚砜抗凝血材料的研究  

Study on heparinizing polyethersulfone as anticoagulant material

作　　者：项昭保[1] 霍丹群[2] 候长军[3] 

机构地区：[1]重庆邮电学院生物信息学院,重庆400065 [2]重庆大学生物力学与组织工程教育部重点实验室,重庆400044 [3]重庆大学化学化工学院,重庆400044

出　　处：《化工新型材料》2005年第9期57-59,共3页New Chemical Materials

基　　金：重庆邮电学院基金项目(A2003-10)

摘　　要：进行了聚醚砜表面共价键合肝素的研究,定性定量检测了改性材料中的肝素,并探讨其力学性能和体外凝血时间,结果表明:肝素共价键合到了聚醚砜表面,表面肝素化改性后的聚醚砜材料基本保持了聚醚砜的力学性能,同时抗凝血性能大大提高。In this paper an approach of covalently immobilizing heparin to the surface of Polyethersulfone（PES） was studied. The heparin in the surface of heparinizd-PES was determined quantitatively and qualitatively. What＇s more, mechanic properties and coagulant time of heparinizd-PES were discussed, the result showed the heparin did be linked to PES materials, the mechanic properties of the heparinized-PES materials were kept primely and its coagulant time was much longer.

关 键 词：肝素 聚醚砜 抗凝血材料 共价键合 改性材料 力学性能 抗凝血性能 定量检测 凝血时间 

分 类 号：R318.08[医药卫生—生物医学工程]