缺血性脑卒中患者血纤溶活性变化规律的研究  

The Study on Tissue Plasminogen Activator Change in Stroke Patients

作　　者：林望[1] 姜建东[1] 

机构地区：[1]南京医科大学附属南京第一医院神经内科,江苏南京210006

出　　处：《中国血液流变学杂志》2005年第3期394-396,共3页Chinese Journal of Hemorheology

摘　　要：目的研究脑梗死组和非脑梗死组患者急性期,亚急性期和恢复期组织型纤溶酶原激活物(tPA),纤溶酶原激活物抑制物-1(PAI-1)的变化规律。方法135例脑梗死组患者于发病96h内,病后14d、3月、6月、9月分别采血,77例非脑梗死组患者先采血一次,然后分别在第一次采血后14d、3月、6月、9月采血。结果脑梗死急性期tPA含量明显升高,PAI-1的含量明显升高。恢复期脑梗死即发病后3月,6月,9月tPA的含量比急性期明显降低,且脑梗死后时间越长tPA含量越低,恢复期脑梗死PAI-1的含量比急性期明显降低。结论在缺血性卒中的患者,高tPA含量提示纤溶活性的降低。高PAI-1代表纤溶抑制增强。Objective Since the possible variation of tissue plasminogen activator （tPA） and plasminogen activator inhibitor-1 （PAI-1） concentrations over time after stroke has been rarely studied, it was examined in plasma from stroke patients in the acute, convalescent and recovery phases of the disease and in a control group. Methods Plasma concentrations of tPA and PAI-1 were detemained in 135 stroke patients and in 77 control subjects. All were reexamined after 14days,3,6,9months respectively. Results In the acute phase, stroke patients had significantly higher tPA and PAI-1 concentrations, both tPA and PAI-1 levels had changed to the baseline when time passed. Conclusions In stroke patients,high tPA concentrations may indicate the decreasing of the fibfinolytic system. High PAI-1 concentrations in patients with cerebral infarction represent increased fibrinolitic inhibition.

关 键 词：脑梗死 纤溶系统 组织型纤溶酶原激活物(tPA) 

分 类 号：R743[医药卫生—神经病学与精神病学]