乳腺癌组织中survivin、c-erbB-2基因的表达与预后的关系  

Relationship of oncogene survivin、c-erbB-2 expression in breast cancer and its prognostic significance

作　　者：毛杰[1] 海健[1] 舒衡平 唐利立[1] 申正堂[1] 邬玉辉[1] 欧慧英[1] 

机构地区：[1]中南大学附属湘雅医院乳腺科,湖南长沙410008 [2]湘雅医学院病原学系,湖南长沙410078

出　　处：《中国癌症杂志》2005年第5期432-434,共3页China Oncology

摘　　要：目的:探讨乳腺癌组织中survivin基因和c-erbB-2基因的表达与预后的关系。方法:用免疫组化S-P法检测80例乳腺癌组织中survivin、c-erbB-2的表达,分析其与腋淋巴结转移和5年无病生存率之间的关系。结果:survivin基因在乳腺癌中阳性表达率为68.75%(55/80)、c-erbB-2基因阳性表达率为36.25%(29/80),均与腋淋巴结转移正相关,与5年生存率负相关(P<0.05);survivin和c-erbB-2表达与肿瘤病理类型、发病年龄、临床分期无明显相关性(P>0.05);survivin和c-erbB-2基因表达相互呈正相关(P<0.05)。结论:凋亡抑制基因survivin和原癌基因c-erbB-2可能在乳腺癌的发生、发展过程中起重要作用,联合检测能更好地判断乳腺癌的预后。Purpose：To investigate the expression of oncogene survivin,e-erbB-2 in breast cancer and its prognostic significance.Methods：Detect the expression of survivin,c-erbB-2 in 80 case breast cancer tissues by immunohistochemistry S-P method,analyze its correlation with axillary lymph node metastasis and 5-year disease free survial （DFS）.Results：Survivin gene positive expression rate was 68.75%（55/80）,c-erbB-2 gene positive expression rate was 36.25%（29/80）in breast cancer tissues,all have positive correlation with the axillary lymph nodes metastasis but negative to 5 years DFS（P〈0.05）;survivin and c-erbB-2 genes expression have no obvious correlation with the breast cancer pathology type,patient age and clinical stage（P〉0.05）,survivin and c-erbB-2 genes expression have positive correlation（P〈0.05）.Conclusions：the anti-apoptosis effect of survivin and c-erbB-2 genes expression have positive corrlation（P〈0.05）.Conclusions：the anti-apoptosis effect of survivin and c-erbB-2 oncogene may be important in the occurrence and advancement of breast cancer,inferring that it can be a new indicator of prognostic and judgement in breast cancer.

关 键 词：乳腺肿瘤 SURVIVIN C-ERBB-2 预后 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]