骨髓增生异常综合征转化为不典型慢性髓性白血病——3例报告并文献复习  

Myelodysplastic syndrome transformed to atypical chronic myeloid leukemia——Three cases report and review of literature

作　　者：陈勤奋[1] 李佩[1] 袁燕[1] 姬美容[1] 谢彦晖[1] 谢毅[1] 林果为[1] 

机构地区：[1]复旦大学附属华山医院血液科,上海200040

出　　处：《中国癌症杂志》2005年第5期473-475,共3页China Oncology

摘　　要：目的:报告3例骨髓增生异常综合征(MDS)转化为不典型慢性髓性白血病(aCML)。方法:比较该3例不同疾病阶段的临床表现、血象和骨髓涂片特征,并复习相关文献进行讨论。结果:本组3例患者均为老年,以慢性贫血起病,行骨髓检查分别诊断为MDS-RAS和MDS-RAEB,未用化疗;在随访中发现白细胞持续升高,以中性粒细胞为主,经骨髓和染色体等检查,诊断为aCML。结论:WHO分类系统将同时具有MDS和骨髓增殖症(MPD)特点的粒细胞疾病归为MDS/MPD,aCML是其中的一种亚型,由MDS自然转化为aCML的病例临床罕见。Purpose：To report three cases of myelodysplastic syndrome（MDS）transformed to atypical chronic myeloid leukemia（aCML）.Methods：Compared the clinical findings.hemograms and hone marrow features in two different courese of the disease,discussed with review of related literatures.Results：The three patients were all old age.They onset with chronic anemia,the results of BM smear were MDS-RAS and MDS-RAEB：Then leukocytosis occurred in 6-65 months.The a CML were diagnosed according to the BM smear and normal chromosome.Conclusions：The MDS/MPD is a new category of the WHO claaification that have both dysplastic and proliferative features.Atypical CML lacks the Ph chromosome and BCR/ABL fusion gene that are the hallmarks of classic CML.This kind of case is seldom seen.

关 键 词：骨髓增生异常综合征 骨髓增生异常综合征/骨髓增殖症 不典型慢性髓性白血病 

分 类 号：R733.72[医药卫生—肿瘤]