中晚期原发性肺癌经动脉灌注化疗联合CT导引肿瘤内注药的疗效观察  

The Observation of Effect on the Treatment of Pulmonary Carcinoma in Middle-advanced Stage by Percutaneous Intratumor Carboplatin Injection under CT Guided in Combination with Artery Chemotherapy

作　　者：李庆[1] 赵新华[2] 龙农[1] 王志强[1] 

机构地区：[1]湘南学院附属医院放射科,湖南郴州423000 [2]湘南学院附属医院肿瘤内科,湖南郴州423000

出　　处：《实用放射学杂志》2005年第10期1074-1077,共4页Journal of Practical Radiology

摘　　要：目的研究支气管动脉灌注化疗(BAI)结合胸廓内动脉灌注化疗(IAI)联合CT导引经皮瘤体内注射化疗药物(PC I)治疗中晚期原发性肺癌的可行性及临床价值。方法治疗组30例Ⅲ、Ⅳ期原发性肺癌,行BAI+IAI+PC I;对照组28例Ⅲ、Ⅳ期原发性肺癌,行BAI+PC I。通过CT、生活质量及生存期等指标观察疗效。结果治疗组近期有效率73.3%,高于对照组46.4%(Ρ<0.05);且生活质量、生存期均有明显提高。结论BAI结合IAI联合CT导引经皮瘤内注射是一种安全有效的治疗方法,能明显改善中晚期原发性肺癌患者的生活质量,提高近期疗效,延长生存期。Objective To investigate the feasibility and clinical value of pulmonary carcinoma in middle - advanced stage by percutaneous intratumor carboplatin injection （PCI） under CT guided in combination with bronchial artery infusion （BAI） and intrathoracic artery infusion（ IAI）. Methods There were totally 58 cases with central bronchial carcinoma in stage Ⅲ and Ⅳ. Of them ,30 cases （ treatment group ） were treated by BAI ＋ IAI and PCI, while 28 patients （ control group ） were treated by BAI and PCI. Therapeutic effect was evaluated according to the improvement of the following variables：CT,life quality and survival period after treatment. Results The responsive rate in the treatment group（73.3% ） was significantly higher than that in the control group （46.4%） , the life quality and survival period were much improved. Conclusion Percutaneous intratumor carboplatin injection in combination with BAI and IAI is a effective method for bronchial carcinoma in Ⅲ and Ⅳ stages,it can not only improve the shorten effect,prolong survival period, but also can improve patients life quality.

关 键 词：胸部 肺癌 介入放射学 动脉灌注 

分 类 号：R734.2[医药卫生—肿瘤] R815[医药卫生—临床医学]