实验性哮喘时神经生长因子对P物质的上调作用  

Up - regulatory effect of nerve growth factor on substance P in the experimental asthma

作　　者：刘晓湘[1] 方秀斌[1] 张鸿[1] 李松林[1] 刘文瑞[1] 

机构地区：[1]中国医科大学神经生物学教研室,辽宁沈阳110001

出　　处：《中国病理生理杂志》2005年第10期1978-1980,共3页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.30070330);辽宁省教育厅基金资助项目(No.20121032)

摘　　要：目的:探讨实验性哮喘时神经生长因子(NGF)对P物质(SP)的调节机制。方法:应用放射免疫分析 方法检测了NGF缺失时(鼻腔吸入NGF抗体)哮喘豚鼠下呼吸道和内脏感觉传入部位SP含量的变化。结果:NGF缺 失时哮喘豚鼠气管、支气管、肺、C7-T5段脊神经节及相应节段脊髓后角、结状神经节和孤束核区SP含量明显低于 哮喘组和对照组(P<0．01)。结论:实验性哮喘时NGF可上调下呼吸道和感觉神经节等内脏感觉传入部位的P物质 水平,两者共同参与支气管哮喘的发病过程。AIM： To explore the regulatory mechanism of nerve growth factor （NGF） on substance P in the experimental asthmatic guinea pig. METHODS： Radioimmunoassay was used to determine the alteration of substance P levels in the lower respiratory tract and visceral sensory afferent sites while NGF was absent （inhalation of NGF antibody through nasal cavity） in the asthmatic guinea pig. RESULTS： The contents of substance P in the trachea, bronchus, lung, Ca - T5 spinal ganglia and the cor- respondent spinal dorsal horn, nodose ganglia and solitary nucleus area in the experimental asthmatic guinea pig with the absent of NGF in the respiratory tract, were much lower than those in the asthmatic and control groups （P 〈 0.01 ）. CONCLUSION： NGF upregulates the contents of substance P in the lower respiratory tract and visceral sensory sites of the experimental asthmatic guinea pig, which might be involved in the pathogenesis of asthma.

关 键 词：神经生长因子类 P物质 哮喘 豚鼠 

分 类 号：R363[医药卫生—病理学]