胚胎发育相关基因(EDAG)的研究进展  

Advances in the Study of EDAG

作　　者：石洋[1] 马小彤[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所血液病医院实验血液学国家重点实验室,天津市300020

出　　处：《医学分子生物学杂志》2005年第5期363-365,372,共4页Journal of Medical Molecular Biology

基　　金：国家自然科学基金(No.30471964)~~

摘　　要：胚胎发育相关基因(EDAG)是新近发现的基因,主要表达于人类造血系统细胞中,可能参与调控造血细胞的增殖、分化。将EDAG稳定表达于小鼠成纤维细胞系NIH3T3中,可导致NIH3T3发生恶性改变。白血病细胞系中EDAG高表达,可能与白血病细胞未分化状态的维持有关。另外还发现,EDAG的表达可以提高NF-kB的转录活性和DNA结合活性,推测NF-_kB可能是EDAG发挥调控功能的途径之一。Embryonic develop associated gene （EDAG）, a recently discovered novel gene, is abundantly expressed in human hematopoietic system. EDAG may play a role in the regulation of the proliferation and differentiation of hematopoietic cells. Stable expression of EDAG in NIH3T3 cells lead to tumor transformation. Overexpression of EDAG in leukemia cell lines may be associated with the maintenance of non-differentiation status of the cells. Furthermore, both the NF-kB transcription and DNA binding activities were highly enhanced by EDAG. EDAG may serve its function through activation of NF-kB.

关 键 词：EDAG 白血病细胞 分化 NF-ΚB 

分 类 号：R733.7[医药卫生—肿瘤]