溶血磷脂酸早期诊断卵巢癌的价值  

Using lysophosphatidic acidose to diagnose ovarian cancer in early stage

作　　者：李成博[1] 唐慧君[1] 

机构地区：[1]大连医科大学第二临床学院妇产科,辽宁大连116027

出　　处：《大连医科大学学报》2005年第5期362-363,共2页Journal of Dalian Medical University

摘　　要：[目的]探讨应用溶血磷脂酸(LPA)早期诊断卵巢癌的价值。[方法]收集卵巢癌35例,良性卵巢肿物34例,两组患者分别进行LPA检测,并对LPA检测结果进行比较。[结果]两种不同标记物检测卵巢癌结果评价,LPA检测卵巢癌的敏感性=85.7%,特异性=94.1%,准确性=89.9%;CA125检测卵巢癌的敏感性=57.1%,特异性=76.5%,准确性=66.7%。[结论]①LPA可能成为一种新的检测卵巢癌标记物。②应用这两种标记物早期诊断卵巢癌,LPA与CA125相比,LPA可能更有临床价值。[ Objective] To investigate the dingnostic value of lysophosphatidic acid （LPA） for early detecting ovarian cancer. [ Methods] Plasma LPA and CA125 levels were determined in 35 cases of ovarian cancer study group, and 34 cases of benign ovarian neoplasma control group. [ Results] Sensitivity of LPA and CA125 are 85.7 % and 57.1%, respectively. Specialitry of LPA and CA125 are 94.1% and 76.5%, respectively. Accuracry of LPA is 89.9% ,Accuracy of CA125 is 66.7%. [Conclusion] 1. LPA is liable to be a new biomarker for detecting ovarian cancer. 2. Determining LPA, we think, is superior to CA125 in early detecting ovarin cancer.

关 键 词：溶血磷脂酸 卵巢癌 CA125 

分 类 号：R737.31[医药卫生—肿瘤]