地塞米松治疗急性胰腺炎的实验研究  

Treatment of acute pancreatitis with dexamethsone: Experimental study

作　　者：吕金利 李永研 李占京[2] 顾红光[2] 

机构地区：[1]153医院普通外科,河南郑州450042 [2]第三军医大学大坪医院肝胆外科,重庆400042

出　　处：《实用医药杂志》2005年第10期906-907,共2页Practical Journal of Medicine & Pharmacy

摘　　要：目的观察地塞米松(D XM)在治疗急性胰腺炎(AP)中的作用及其机制。方法腹腔内注射L-精氨酸的方法制作小鼠急性胰腺炎模型。动物随机分为3组;A组10只:动物不做任何处理;B组30只:A P模型制作后1h经鼠尾静脉注入生理盐水对照;C组30只:地塞米松(4m g/kg)治疗组;观察24h各组小鼠的病死率,RT-PCR方法检测两组小鼠肝肺组织白细胞介素-1β(IL-1β)表达。结果地塞米松治疗组小鼠病死率显著低于盐水对照组,地塞米松治疗组小鼠肝肺组织IL-1β的表达显著低于盐水对照组IL-1β的表达。结论早期大剂量注射地塞米松可通过降低急性胰腺炎急性期炎症因子的表达来降低急性胰腺炎小鼠的病死率。Objective To observe the therapeutic effects and mechanisms of dexamethsone （DXM） on acute pancreatitis （AP）.Methods The AP model was induced by injecting L-arginine （Arg） to the abdominal Cavity of mice, the animals were randomly divided into 3 groups; Group A（n=10）： no treatment were given to the animals; Group B（n=30）：intravenecus injection through tail vein with saline 1 hour after AP models; Group C（n=30）： DXM（4mg/kg） treatment. The 24h death rate was observed in every group, the expression of interleukin-1β in liver and lung tissue were detected by reverse transcription polymerase chain reaction（RT-PCR）. Result Group C had a lower death rate （13.3%） than Group B （53.3%）;In expressions of interleukin-1β in liver and lung tissue there was significant difference between Group B and Group C. Conclusion Early large dosage of DXM may reduce the death rate of AP mice by restraining expression of acutephase tissue inflammatory factor.

关 键 词：急性胰腺炎 地塞米松 病死率 白细胞介素 

分 类 号：R576[医药卫生—消化系统] R965.1[医药卫生—内科学]